{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:17:41Z","timestamp":1780546661313,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T00:00:00Z","timestamp":1510617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR\u2010057578"],"award-info":[{"award-number":["AR\u2010057578"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR\u2010064850"],"award-info":[{"award-number":["AR\u2010064850"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care & Research"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Objective<\/jats:title>Previous cross\u2010sectional studies have shown that rheumatoid arthritis (RA<\/jats:styled-content>) patients with fibromyalgia (FM<\/jats:styled-content>) have higher disease activity, greater medical costs, and worse quality of life compared to RA<\/jats:styled-content> patients without FM<\/jats:styled-content>. We determined the impact of FM<\/jats:styled-content> on 2\u2010year changes in the functional status of RA<\/jats:styled-content> patients in a prospective study.<\/jats:p><\/jats:sec>Methods<\/jats:title>Subjects included participants in the Brigham Rheumatoid Arthritis Sequential Study who were enrolled in a substudy of the effects of pain in RA<\/jats:styled-content>. Subjects completed questionnaires, including the Multi\u2010Dimensional Health Assessment Questionnaire (MDHAQ<\/jats:styled-content>) and Polysymptomatic Distress (PSD<\/jats:styled-content>) scale, semiannually, and underwent physical examination and laboratory tests yearly.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the 156 included RA<\/jats:styled-content> subjects, 16.7% had FM<\/jats:styled-content>, while 83.3% did not. In a multivariable linear regression model adjusted for age, sex, race, baseline MDHAQ<\/jats:styled-content> score, disease duration, rheumatoid factor\/cyclic citrullinated peptide antibody seropositivity, disease activity, and psychological distress, RA<\/jats:styled-content> patients with FM<\/jats:styled-content> had a 0.14 greater 2\u2010year increase in MDHAQ<\/jats:styled-content> score than RA<\/jats:styled-content> patients without FM<\/jats:styled-content> (P<\/jats:italic> = 0.021). In secondary analyses examining the association between continuous PSD<\/jats:styled-content> scale score and change in MDHAQ<\/jats:styled-content>, higher PSD<\/jats:styled-content> scale scores were significantly associated with greater 2\u2010year increases in MDHAQ<\/jats:styled-content> score (\u03b2 coefficient 0.013, P<\/jats:italic> = 0.011).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Both the presence of FM<\/jats:styled-content> and increasing number of FM<\/jats:styled-content> symptoms predicted worsening of functional status among individuals with RA<\/jats:styled-content>. Among individuals with RA<\/jats:styled-content> and FM<\/jats:styled-content>, the magnitude of the difference in changes in MDHAQ<\/jats:styled-content> was 4\u2010 to 7\u2010fold higher than typical changes in MDHAQ<\/jats:styled-content> score among individuals with established RA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23216","type":"journal-article","created":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T14:46:14Z","timestamp":1486651574000},"page":"1871-1877","source":"Crossref","is-referenced-by-count":15,"title":["Fibromyalgia and the Prediction of Two\u2010Year Changes in Functional Status in Rheumatoid Arthritis Patients"],"prefix":"10.1002","volume":"69","author":[{"given":"Hyein","family":"Kim","sequence":"first","affiliation":[{"name":"University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cui","sequence":"additional","affiliation":[{"name":"Brigham 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