{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:32:44Z","timestamp":1792290764194,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T00:00:00Z","timestamp":1509926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32\u2010AR\u2010007442\u201028"],"award-info":[{"award-number":["5T32\u2010AR\u2010007442\u201028"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P60\u2010AR\u2010053308"],"award-info":[{"award-number":["P60\u2010AR\u2010053308"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["CX000896"],"award-info":[{"award-number":["CX000896"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["IK2 CX000955"],"award-info":[{"award-number":["IK2 CX000955"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care & Research"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Objective<\/jats:title>The C\u2010reactive protein (CRP<\/jats:styled-content>) level and erythrocyte sedimentation rate (ESR<\/jats:styled-content>) are important disease activity biomarkers in rheumatoid arthritis (RA<\/jats:styled-content>). This study aimed to determine to what extent obesity biases these biomarkers.<\/jats:p><\/jats:sec>Methods<\/jats:title>Body mass index (BMI<\/jats:styled-content>) associations with CRP<\/jats:styled-content> level and ESR<\/jats:styled-content> were assessed in 2 RA<\/jats:styled-content> cohorts: the cross\u2010sectional Body Composition (BC<\/jats:styled-content>) cohort (n = 451), including whole\u2010body dual x\u2010ray absorptiometry measures of fat mass index; and the longitudinal Veterans Affairs Rheumatoid Arthritis (VARA<\/jats:styled-content>) registry (n = 1,652), using multivariable models stratified by sex. For comparison, associations were evaluated in the general population using the National Health and Nutrition Examination Survey.<\/jats:p><\/jats:sec>Results<\/jats:title>Among women with RA<\/jats:styled-content> and in the general population, greater BMI<\/jats:styled-content> was associated with greater CRP<\/jats:styled-content> levels, especially among women with severe obesity (P<\/jats:italic> < 0.001 for BMI<\/jats:styled-content> \u226535 kg\/m2<\/jats:sup> versus 20\u201325 kg\/m2<\/jats:sup>). This association remained after adjustment for joint counts and patient global health scores (P<\/jats:italic> < 0.001 in BC<\/jats:styled-content> and P<\/jats:italic> < 0.01 in VARA<\/jats:styled-content>), but was attenuated after adjustment for fat mass index (P<\/jats:italic> = 0.17). Positive associations between BMI<\/jats:styled-content> and ESR<\/jats:styled-content> in women were more modest. In men with RA<\/jats:styled-content>, lower BMI<\/jats:styled-content> was associated with higher CRP<\/jats:styled-content> levels and ESR<\/jats:styled-content>, contrasting with positive associations among men in the general population.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Obesity is associated with higher CRP<\/jats:styled-content> levels and ESR<\/jats:styled-content> in women with RA<\/jats:styled-content>. This association is related to fat mass and not RA<\/jats:styled-content> disease activity. Low BMI<\/jats:styled-content> is associated with higher CRP<\/jats:styled-content> levels in men with RA<\/jats:styled-content>; this unexpected finding remains incompletely explained but likely is not a direct effect of adiposity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23229","type":"journal-article","created":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T01:02:57Z","timestamp":1491786177000},"page":"1789-1798","source":"Crossref","is-referenced-by-count":79,"title":["Impact of Obesity and Adiposity on Inflammatory Markers in Patients With Rheumatoid Arthritis"],"prefix":"10.1002","volume":"69","author":[{"given":"Michael D.","family":"George","sequence":"first","affiliation":[{"name":"University of Pennsylvania Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon T.","family":"Giles","sequence":"additional","affiliation":[{"name":"Columbia University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia 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University of Pennsylvania Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant W.","family":"Cannon","sequence":"additional","affiliation":[{"name":"Salt Lake City VA Medical Center and University of Utah Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liron","family":"Caplan","sequence":"additional","affiliation":[{"name":"Denver VA Medical Center and University of Colorado School of Medicine Denver"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian C.","family":"Sauer","sequence":"additional","affiliation":[{"name":"University of Utah Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua F.","family":"Baker","sequence":"additional","affiliation":[{"name":"Philadelphia VA Medical Center and University of Pennsylvania 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