{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:06:39Z","timestamp":1787875599652,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T00:00:00Z","timestamp":1509062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009109","name":"Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002429","name":"Amgen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011110","name":"UCB","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011110","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To characterize psoriatic arthritis (PsA) patients with dactylitis or enthesitis and evaluate the associations of these manifestations with disease activity and patient\u2010reported outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the Corrona PsA\/Spondyloarthritis Registry, patient characteristics, disease activity, and patient\u2010reported outcomes at registry enrollment were assessed for PsA patients ages \u226518 years with or without dactylitis or enthesitis. Regression models were used to evaluate associations of dactylitis and enthesitis with outcomes, including minimal disease activity, Health Assessment Questionnaire scores, patient\u2010reported pain and fatigue, and work productivity (Work Productivity and Activity Impairment questionnaire). Adjustments were made for age, sex, race, body mass index, disease duration, and history of biologic agent, disease\u2010modifying antirheumatic drug, and prednisone use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This analysis included 1,567 PsA patients (420 with enthesitis; 228 with dactylitis). Patients with versus without dactylitis or enthesitis had greater disease activity and were less likely to be in minimal disease activity (<jats:italic>P<\/jats:italic> &lt; 0.05). Patients with versus without enthesitis had poorer functional status as assessed by the Health Assessment Questionnaire (adjusted <jats:italic>P<\/jats:italic> = 4.15 x 10<jats:sup>\u22125<\/jats:sup>), greater patient\u2010reported pain and fatigue (adjusted <jats:italic>P<\/jats:italic> &lt; 0.0001), and greater likelihood of any impairment while working (adjusted odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>] 1.57, <jats:italic>P<\/jats:italic> = 0.027), overall work impairment (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.85, <jats:italic>P<\/jats:italic> = 0.006), and activity impairment (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.77, <jats:italic>P<\/jats:italic> = 0.008). Dactylitis was associated with similar numerical trends, but differences versus patients without dactylitis did not reach statistical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Enthesitis and dactylitis are associated with greater overall disease burden of PsA, underscoring the importance of identifying, assessing, and effectively managing these periarticular manifestations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23249","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T13:19:07Z","timestamp":1491398347000},"page":"1692-1699","source":"Crossref","is-referenced-by-count":112,"title":["Clinical Characteristics, Disease Activity, and Patient\u2010Reported Outcomes in Psoriatic Arthritis Patients With Dactylitis or Enthesitis: Results From the Corrona Psoriatic Arthritis\/Spondyloarthritis Registry"],"prefix":"10.1002","volume":"69","author":[{"given":"Philip J.","family":"Mease","sequence":"first","affiliation":[{"name":"Swedish Medical Center and University of Washington School of Medicine Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitra","family":"Karki","sequence":"additional","affiliation":[{"name":"Corrona Southborough Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline B.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals East Hanover New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol J.","family":"Etzel","sequence":"additional","affiliation":[{"name":"Corrona, and The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Kavanaugh","sequence":"additional","affiliation":[{"name":"University of California at San Diego La Jolla"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"Ritchlin","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendi","family":"Malley","sequence":"additional","affiliation":[{"name":"Corrona Southborough Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Herrera","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals East Hanover New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melody","family":"Tran","sequence":"additional","affiliation":[{"name":"Scott&amp; White Health Plan Temple Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Corrona and New York University School of Medicine New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1833"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.140582"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.018184"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341536"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.04.005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v5.i4.537"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.150165"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201617"},{"key":"e_1_2_8_10_1","first-page":"219","article-title":"Ultrasound detects occult entheseal involvement in early psoriatic arthritis independently of clinical features and psoriatic severity","volume":"31","author":"Bandinelli F","year":"2013","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205839"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39573"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200350"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.150995"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140878"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.102053"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230202"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-199304050-00006"},{"key":"e_1_2_8_19_1","first-page":"2082","article-title":"Psoriatic arthritis in Reykjavik, Iceland: prevalence, demographics, and disease course","volume":"34","author":"Love TJ","year":"2007","journal-title":"J Rheumatol"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130163"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120254"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203696"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412679"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100069"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2011.12.003"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140259"}],"container-title":["Arthritis Care &amp; 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