{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:45:57Z","timestamp":1788911157615,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the prevalence, associated characteristics, and course of enthesitis in a juvenile idiopathic arthritis (<jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>) inception cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Canadian children newly diagnosed with <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> between 2005 and 2010 were categorized using International League of Associations for Rheumatology criteria at the 6\u2010month visit and followed in the Research in Arthritis in Canadian Children Emphasizing Outcomes (Re<jats:styled-content style=\"fixed-case\">ACC<\/jats:styled-content>h\u2010Out) cohort for up to 5 years. The presence of entheseal tenderness on examination at 33 sites shown on a homunculus was recorded at 0, 6, 12, 18, 24, 36, 48, and 60 months after enrollment. Enthesitis was defined as entheseal tenderness at more than 1 site or on more than 1 occasion. Analyses consisted of descriptive statistics and linear mixed models for longitudinal data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1,406 patients, 219 (16%) had enthesitis and, of those with enthesitis, 141 (64%) were classified as having enthesitis\u2010related arthritis (<jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content>). Children with enthesitis were more often older (10.7 versus 7.5 years), male (57% versus 31%), and with polyarthritis (57% versus 41%) and sacroiliac involvement (30% versus 4%). Entheseal tenderness was most frequent at the calcaneal plantar fascial insertion (39%), Achilles tendon insertion (31%), and tibial tuberosity (30%). The mean number of tender entheseal sites decreased in parallel with active joint counts. There was no difference in active joint counts over time in children with or without enthesitis (<jats:italic>P<\/jats:italic> = 0.73).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Enthesitis was observed in 16% of patients with <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>, but only two thirds were categorized as having <jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content>. Contrary to expectations, most children with enthesitis had polyarticular involvement. The course of enthesitis paralleled the course of active joint counts.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23256","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T16:00:00Z","timestamp":1492704000000},"page":"303-308","source":"Crossref","is-referenced-by-count":23,"title":["Characteristics and Course of Enthesitis in a Juvenile Idiopathic Arthritis Inception Cohort"],"prefix":"10.1002","volume":"70","author":[{"given":"Dax G.","family":"Rumsey","sequence":"first","affiliation":[{"name":"University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Guzman","sequence":"additional","affiliation":[{"name":"University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan M.","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"University of Saskatchewan Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Huber","sequence":"additional","affiliation":[{"name":"IWK Health Centre and Dalhousie University Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosie","family":"Scuccimarri","sequence":"additional","affiliation":[{"name":"McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie J.","family":"Shiff","sequence":"additional","affiliation":[{"name":"University of Florida Gainesville"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Bruns","sequence":"additional","affiliation":[{"name":"University of Sherbrooke Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Feldman","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children and the University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean T.","family":"Eurich","sequence":"additional","affiliation":[{"name":"University of Alberta Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Research in Arthritis in Canadian Children Emphasizing Outcomes Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-24145-8.00015-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22173"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.103"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20508"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120642"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.121257"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.084244"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205372"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(02)00033-9"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780250902"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-24145-8.00019-3"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-10-S1-A41"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.150555"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39458"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22665"}],"container-title":["Arthritis Care &amp; 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