{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:04:14Z","timestamp":1792206254853,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["NO1\u2010DE\u201032636 and HHSN26S201300057C"],"award-info":[{"award-number":["NO1\u2010DE\u201032636 and HHSN26S201300057C"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1\u2010DE\u201012354\u201015A1"],"award-info":[{"award-number":["RO1\u2010DE\u201012354\u201015A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2018,2]]},"abstract":"\n Objective<\/jats:title>\n \n To explore changes in the phenotypic features of Sj\u00f6gren's syndrome (\n SS<\/jats:styled-content>\n ), and in\n SS<\/jats:styled-content>\n status among participants in the Sj\u00f6gren's International Collaborative Clinical Alliance (\n SICCA<\/jats:styled-content>\n ) registry over a 2\u20133\u2010year interval.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n All participants in the\n SICCA<\/jats:styled-content>\n registry who were found to have any objective measures of salivary hypofunction, dry eye, focal lymphocytic sialadenitis in minor salivary gland biopsy, or anti\u2010\n SSA<\/jats:styled-content>\n \/\n SSB<\/jats:styled-content>\n antibodies were recalled over a window of 2 to 3 years after their baseline examinations to repeat all clinical examinations and specimen collections to determine whether there was any change in phenotypic features and in\n SS<\/jats:styled-content>\n status.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n As of September 15, 2013, a total of 3,514 participants had enrolled in\n SICCA<\/jats:styled-content>\n , and among 3,310 eligible, 771 presented for a followup visit. Among participants found to have\n SS<\/jats:styled-content>\n using the 2012 American College of Rheumatology (\n ACR<\/jats:styled-content>\n ) classification criteria, 93% again met the criteria after 2 to 3 years, and this proportion was 89% when using the 2016\n ACR<\/jats:styled-content>\n \/European League Against Rheumatism (\n EULAR<\/jats:styled-content>\n ) criteria. Among those who did not meet\n ACR<\/jats:styled-content>\n or\n ACR<\/jats:styled-content>\n \/\n EULAR<\/jats:styled-content>\n criteria at baseline, 9% and 8%, respectively, had progressed and met them at followup. Those with hypergammaglobulinemia and hypocomplementemia at study entry were, respectively, 4 and 6 times more likely to progress to\n SS<\/jats:styled-content>\n by\n ACR<\/jats:styled-content>\n criteria than those without these characteristics (95% confidence interval 1.5\u201310.1 and 1.8\u201320.4, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n While there was stability over a 2\u20133\u2010year period of both individual phenotypic features of\n SS<\/jats:styled-content>\n and of\n SS<\/jats:styled-content>\n status, hypergammaglobulinemia and hypocomplementemia at study entry were predictive of progression to\n SS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/acr.23264","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T16:56:44Z","timestamp":1493053004000},"page":"284-294","source":"Crossref","is-referenced-by-count":64,"title":["Natural History and Predictors of Progression to Sj\u00f6gren's Syndrome Among Participants of the Sj\u00f6gren's International Collaborative Clinical Alliance Registry"],"prefix":"10.1002","volume":"70","author":[{"given":"Caroline H.","family":"Shiboski","sequence":"first","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan N.","family":"Baer","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Shiboski","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Lam","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Challacombe","sequence":"additional","affiliation":[{"name":"King's 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