{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:47:39Z","timestamp":1791582459169,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["Ul1\u2010TR\u2010000004"],"award-info":[{"award-number":["Ul1\u2010TR\u2010000004"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1\u2010TR\u2010001872"],"award-info":[{"award-number":["UL1\u2010TR\u2010001872"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arthritis Care & Research"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Objective<\/jats:title>To compare major depression risk among young adults with juvenile\u2010onset and adult\u2010onset systemic lupus erythematosus (SLE<\/jats:styled-content>), and to determine demographic and health\u2010related predictors of depression.<\/jats:p><\/jats:sec>Methods<\/jats:title>Young adults with SLE<\/jats:styled-content> ages 18\u201345 years (n = 546) in the Lupus Outcomes Study completed annual telephone surveys from 2002\u20132015, including assessment of depression using the Center for Epidemiologic Studies Depression Scale (CES<\/jats:styled-content>\u2010D), and self\u2010report measures of sociodemographics and health characteristics. Juvenile\u2010onset SLE<\/jats:styled-content> was defined as age <18 years at diagnosis (n = 115). Repeated\u2010measures analysis was performed to assess the risk for major depression (CES<\/jats:styled-content>\u2010D \u226524) at any point in study, and logistic regression was used to assess for recurrent (present on \u22652 assessments) major depression.<\/jats:p><\/jats:sec>Results<\/jats:title>Major depression was experienced by 47% of the cohort at least once during the 12\u2010year study period. In adjusted analyses, juvenile\u2010onset SLE<\/jats:styled-content> patients had an increased risk of having a major depressive episode (odds ratio [OR<\/jats:styled-content>] 1.7 [95% confidence interval (95% CI<\/jats:styled-content>) 1.0\u20132.7]) and recurrent episodes (OR<\/jats:styled-content> 2.2 [95% CI<\/jats:styled-content> 1.2\u20134.3]), compared to participants with adult\u2010onset SLE<\/jats:styled-content>. Older age, lower educational attainment, and physical function, higher disease activity, and a history of smoking were associated with an increased depression risk. Juvenile\u2010onset SLE<\/jats:styled-content> patients had a higher risk of major depression across all educational groups.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Young adults with SLE<\/jats:styled-content>, particularly those with juvenile\u2010onset disease, are at high risk for major depression, which is associated with increased disease activity, poorer physical functioning, and lower educational attainment. Early depression intervention in young adults with SLE<\/jats:styled-content> has the potential to improve both medical and psychosocial outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23290","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T21:11:27Z","timestamp":1495573887000},"page":"475-480","source":"Crossref","is-referenced-by-count":58,"title":["Depression Risk in Young Adults With Juvenile\u2010 and Adult\u2010Onset Lupus: Twelve Years of Followup"],"prefix":"10.1002","volume":"70","author":[{"given":"Andrea M.","family":"Knight","sequence":"first","affiliation":[{"name":"The Children's Hospital of Philadelphia Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Trupin","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Katz","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Yelin","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica F.","family":"Lawson","sequence":"additional","affiliation":[{"name":"University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203313477227"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24236"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20426"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.593"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-12-42"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.1.66"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22481"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199904)42:4<599::AID-ANR2>3.0.CO;2-F"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20447"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203303lu332oa"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.306.6890.1437"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-015-1083-5"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0898264308321002"},{"key":"e_1_2_6_15_1","first-page":"S92","article-title":"Depression: the benefits of early and appropriate treatment","volume":"13","author":"Halfin A","year":"2007","journal-title":"Am J Manag Care"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1746-1561.2012.00710.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22228"}],"container-title":["Arthritis Care & Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.23290","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.23290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T14:32:39Z","timestamp":1759415559000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.23290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,26]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1002\/acr.23290"],"URL":"https:\/\/doi.org\/10.1002\/acr.23290","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,26]]}}}