{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:44:39Z","timestamp":1759452279097,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:00:00Z","timestamp":1586304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The present study was undertaken to investigate the joint distribution and 2\u2010year outcome of patients with recent\u2010onset monoarthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult patients with clinically apparent monoarthritis of \u226416 weeks\u2019 duration were included in a multicenter 2\u2010year longitudinal study. Clinical characteristics, joint distribution, development of chronic inflammatory rheumatic disease (CIRD), as well as classification criteria according to the American College of Rheumatology (ACR)\/European League Against Rheumatism (EULAR) 2010 criteria for RA were studied. Predictors for development of CIRD were analyzed by multivariable logistic regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The knee (49.3%), ankle (16.7%), and wrist (14.1%) were the most frequently affected joints among the 347 included patients. A total of 91 patients (26.2%) developed CIRD during follow\u2010up; 21 (6.1%) were diagnosed with RA, and 16 (4.6%) with psoriatic arthritis. Longer duration of joint swelling, joint localization, and anti\u2013citrullinated protein antibody (ACPA) and rheumatoid factor (RF) positivity were independent predictors of CIRD. Six of 58 patients (10.3%) with ankle monoarthritis and 21 of 49 patients (42.9%) with wrist monoarthritis developed CIRD during follow\u2010up. The 2010 ACR\/EULAR Criteria for RA identified all patients diagnosed with seropositive RA at an early stage, mostly within 3 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Approximately one\u2010fourth of patients with recent\u2010onset monoarthritis developed CIRD over 2 years. Patients presenting with ankle arthritis rarely developed CIRD, whereas patients presenting with wrist arthritis more frequently did so. Longer duration of joint swelling and ACPA and RF positivity were also predictive of CIRD. Our findings facilitate the early identification of patients with monoarthritis who have an unfavorable prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23334","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T16:52:37Z","timestamp":1501865557000},"page":"705-710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Joint Distribution and Two\u2010Year Outcome in 347 Patients With Monoarthritis of Less Than Sixteen Weeks\u2019 Duration"],"prefix":"10.1002","volume":"72","author":[{"given":"Ellen Sauar","family":"Norli","sequence":"first","affiliation":[{"name":"Martina Hansens Hospital, Sandvika, Norway, Diakonhjemmet Hospital, and University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gina Hetland","family":"Brinkmann","sequence":"additional","affiliation":[{"name":"\u00d8stfold Hospital Trust, Gr\u00e5lum, Norway, and Diakonhjemmet Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tore Kristian","family":"Kvien","sequence":"additional","affiliation":[{"name":"Diakonhjemmet Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olav","family":"Bj\u00f8rneboe","sequence":"additional","affiliation":[{"name":"Martina Hansens Hospital  Sandvika Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Julsrud","family":"Haugen","sequence":"additional","affiliation":[{"name":"\u00d8stfold Hospital Trust  Gr\u00e5lum Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halvor","family":"Nygaard","sequence":"additional","affiliation":[{"name":"Lillehammer Hospital For Rheumatic Diseases  Lillehammer Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathrine","family":"Thunem","sequence":"additional","affiliation":[{"name":"Betanien Hospital  Skien Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Lie","sequence":"additional","affiliation":[{"name":"Diakonhjemmet Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Dahl","family":"Mjaavatten","sequence":"additional","affiliation":[{"name":"Diakonhjemmet Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.78"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12259"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780301206"},{"key":"e_1_2_7_5_1","first-page":"2351","article-title":"Outcome of early monoarthritis: a followup study","volume":"34","author":"Binard A","year":"2007","journal-title":"J Rheumatol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2995"},{"key":"e_1_2_7_7_1","first-page":"209","article-title":"Outcome of patients with undifferentiated chronic monoarthritis: retrospective study of 46 cases","volume":"71","author":"Inaoui R","year":"2004","journal-title":"Lancet"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.34.2.171"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009748309099744"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081217"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.130310"},{"key":"e_1_2_7_13_1","first-page":"533","article-title":"Diagnostic outcomes associated with ankle synovitis in early inflammatory arthritis: a cohort study","volume":"32","author":"Abhishek A","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.07.004"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203284"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208873"}],"container-title":["Arthritis Care &amp; 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