{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:55:27Z","timestamp":1790074527472,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009123","name":"Norges Teknisk-Naturvitenskapelige Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009123","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007465","name":"Universitetet i Troms\u00f8","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007465","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003549","name":"Orsz\u00e1gos Tudom\u00e1nyos Kutat\u00e1si Alapprogramok","doi-asserted-by":"publisher","award":["108444"],"award-info":[{"award-number":["108444"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005366","name":"Universitetet i Oslo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005366","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006133","name":"Anders Jahres Fond til Vitenskapens Fremme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006133","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      In juvenile dermatomyositis (\n                      <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                      ), microvascular abnormalities, measured by nailfold capillaroscopy (\n                      <jats:styled-content style=\"fixed-case\">NFC<\/jats:styled-content>\n                      ), are common early in the disease course. We aimed to compare the presence of\n                      <jats:styled-content style=\"fixed-case\">NFC<\/jats:styled-content>\n                      abnormalities in patients with medium\u2010 to long\u2010term juvenile\n                      <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                      with that of controls, and to explore associations between\n                      <jats:styled-content style=\"fixed-case\">NFC<\/jats:styled-content>\n                      abnormalities and disease activity and other disease characteristics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010eight juvenile\n                      <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                      patients with a median disease duration of 16.8 (range 2\u201338) years were clinically examined and compared with matched controls. By\n                      <jats:styled-content style=\"fixed-case\">NFC<\/jats:styled-content>\n                      , we assessed nailfold capillary density (\n                      <jats:styled-content style=\"fixed-case\">NCD<\/jats:styled-content>\n                      ), giant capillaries, scleroderma, and neovascular pattern (defined as scleroderma active or late pattern).\n                      <jats:styled-content style=\"fixed-case\">NFC<\/jats:styled-content>\n                      was analyzed with researchers blinded to patient\/control identity and disease characteristics. We measured disease activity and damage by validated tools, and patients were categorized as having active or inactive disease according to the Paediatric Rheumatology International Trials Organisation criteria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to controls, patients had decreased\n                      <jats:styled-content style=\"fixed-case\">NCD<\/jats:styled-content>\n                      (mean \u00b1\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      6.4 \u00b1 2.1\/mm versus 7.6 \u00b1 0.8\/mm;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001) and showed more abnormality in all other\n                      <jats:styled-content style=\"fixed-case\">NFC<\/jats:styled-content>\n                      parameters; 36% of patients versus 4% of controls had\n                      <jats:styled-content style=\"fixed-case\">NCD<\/jats:styled-content>\n                      &lt;6\/mm (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). Giant capillaries, scleroderma, and neovascular pattern were found in 9%, 84%, and 41% of patients, respectively. Patients with active disease (n = 30) presented more frequently with neovascular pattern than patients with inactive disease (n = 28) (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.041). Decreased\n                      <jats:styled-content style=\"fixed-case\">NCD<\/jats:styled-content>\n                      and neovascular pattern were associated with higher levels of disease activity and impaired muscle function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      After medium\u2010 to long\u2010term followup, juvenile\n                      <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                      patients had decreased\n                      <jats:styled-content style=\"fixed-case\">NCD<\/jats:styled-content>\n                      and, often, neovascular pattern; both were associated with higher levels of disease activity and impaired muscle function. This suggests that\n                      <jats:styled-content style=\"fixed-case\">NFC<\/jats:styled-content>\n                      can be a biomarker for disease activity in longstanding juvenile\n                      <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>\n                      too.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.23338","type":"journal-article","created":{"date-parts":[[2017,8,13]],"date-time":"2017-08-13T22:02:38Z","timestamp":1502661758000},"page":"768-776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Assessment of Microvascular Abnormalities by Nailfold Capillaroscopy in Juvenile Dermatomyositis After Medium\u2010 to Long\u2010Term Followup"],"prefix":"10.1002","volume":"70","author":[{"given":"Zoltan","family":"Barth","sequence":"first","affiliation":[{"name":"Institute for Experimental Medical Research Oslo University Hospital\u2013Ullev\u00e5l and University of Oslo and Bj\u00f8rknes University College, Oslo, Norway and the Institute for Translational Medicine University of P\u00e9cs Medical School P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit N.","family":"Witczak","sequence":"additional","affiliation":[{"name":"Institute for Experimental Medical Research Oslo University Hospital\u2010Ullev\u00e5l and University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit","family":"Flat\u00f8","sequence":"additional","affiliation":[{"name":"Oslo University Hospital\u2013Rikshospitalet and Institute for Clinical Medicine, University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akos","family":"Koller","sequence":"additional","affiliation":[{"name":"University of P\u00e9cs Medical School, P\u00e9cs, Hungary and Institute of Natural Sciences University of Physical Education Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0131-2036","authenticated-orcid":false,"given":"Ivar","family":"Sjaastad","sequence":"additional","affiliation":[{"name":"Institute for Experimental Medical Research OsloUniversity Hospital\u2013Ullev\u00e5l and University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helga","family":"Sanner","sequence":"additional","affiliation":[{"name":"Oslo University Hospital\u2013Rikshospitalet Oslo 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