{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:20:14Z","timestamp":1792718414702,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T00:00:00Z","timestamp":1523491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare microvascular damages on nailfold capillaroscopy (<jats:styled-content style=\"fixed-case\">NFC<\/jats:styled-content>) with macrovascular manifestations evaluated by hand power Doppler ultrasonography (<jats:styled-content style=\"fixed-case\">PDUS<\/jats:styled-content>) in systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) patients, and to assess the associations of these damages with the main digital manifestations of the disease: digital ulcers, acroosteolysis, and calcinosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">NFC<\/jats:styled-content>, hand radiographs, and <jats:styled-content style=\"fixed-case\">PDUS<\/jats:styled-content> were systematically performed in 64 unselected <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients. <jats:styled-content style=\"fixed-case\">PDUS<\/jats:styled-content> evaluation with assessment of ulnar artery occlusion (<jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content>) and finger pulp blood flow (<jats:styled-content style=\"fixed-case\">FPBF<\/jats:styled-content>) were performed blinded for the results of radiographs and <jats:styled-content style=\"fixed-case\">NFC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content> and pathologic <jats:styled-content style=\"fixed-case\">FPBF<\/jats:styled-content> were associated with severe capillary loss (&lt;4 capillaries\/mm) on <jats:styled-content style=\"fixed-case\">NFC<\/jats:styled-content> (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>] 4.04 [95% confidence interval (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 1.23\u201313.29]; <jats:italic>P<\/jats:italic> &lt; 0.05, and <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.38 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.03\u201311.05]; <jats:italic>P<\/jats:italic> &lt; 0.05, respectively). Digital ulcer history was associated with <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 10.71 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.36\u201334.13]; <jats:italic>P<\/jats:italic> &lt; 0.0001), pathologic <jats:styled-content style=\"fixed-case\">FPBF<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 7.67 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.52\u201323.28]; <jats:italic>P<\/jats:italic> &lt; 0.0001), late <jats:styled-content style=\"fixed-case\">NFC<\/jats:styled-content> pattern (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 6.33 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.03\u201319.68]; <jats:italic>P<\/jats:italic> = 0.001), and severe capillary loss (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 8.52 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.15\u201333.78]; <jats:italic>P<\/jats:italic> = 0.001). Acroosteolysis was also associated with <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 15.83 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.95\u201363.54]; <jats:italic>P<\/jats:italic> &lt; 0.0001), pathologic <jats:styled-content style=\"fixed-case\">FPBF<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 5.52 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.71\u201317.90]; <jats:italic>P<\/jats:italic> = 0.003), late <jats:styled-content style=\"fixed-case\">NFC<\/jats:styled-content> pattern (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 6.86 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.18\u201321.53]; <jats:italic>P<\/jats:italic> = 0.001), and severe capillary loss (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 7.20 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.16\u201324.02]; <jats:italic>P<\/jats:italic> = 0.001). Calcinosis on radiographs was associated with late <jats:styled-content style=\"fixed-case\">NFC<\/jats:styled-content> pattern (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 5.41 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.82\u201316.12]; <jats:italic>P<\/jats:italic> = 0.002), severe capillary loss (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 12.69 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.14\u201351.26]; <jats:italic>P<\/jats:italic> &lt; 0.0001), and <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.19 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.14\u20138.92]; <jats:italic>P<\/jats:italic> = 0.025). Combination of <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content> and severe capillary loss in the same patient was especially associated with digital ulcer history (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 18.60 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.24\u2013154.34]; <jats:italic>P<\/jats:italic> = 0.001) and acroosteolysis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 10.83 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.56\u201345.88]; <jats:italic>P<\/jats:italic> = 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Microvascular damages evaluated by <jats:styled-content style=\"fixed-case\">NFC<\/jats:styled-content> and macrovascular features like <jats:styled-content style=\"fixed-case\">UAO<\/jats:styled-content> assessed by <jats:styled-content style=\"fixed-case\">PDUS<\/jats:styled-content> show concordant associations with the main digital manifestations of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23413","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T16:52:43Z","timestamp":1505235163000},"page":"938-943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Combination of Capillaroscopic and Ultrasonographic Evaluations in Systemic Sclerosis: Results of a Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"70","author":[{"given":"Alain","family":"Lescoat","sequence":"first","affiliation":[{"name":"CHU Rennes University of Rennes and UMR INSERM U1085 Research Institute in Health, Environment, and Occupation Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Coiffier","sequence":"additional","affiliation":[{"name":"CHU Rennes University of Rennes and UMR INSERM U991 Rennes 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