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Women's Health Initiative data were linked to Medicare claims data to determine TKR<\/jats:styled-content> (n = 1,867) and THR<\/jats:styled-content> (n = 944) for OA<\/jats:styled-content>. Women were followed for up to 18 years after undergoing THR<\/jats:styled-content> or TKR<\/jats:styled-content> to determine mobility status at age 85 years.<\/jats:p><\/jats:sec>Results<\/jats:title>Compared with normal\u2010weight women, overweight, obese I, and obese II<\/jats:styled-content> women with THR<\/jats:styled-content> had significantly increased risk of survival to age 85 years with mobility limitation (P<\/jats:italic> < 0.001 for linear trend), with the strongest risk among obese II<\/jats:styled-content> women (odds ratio [OR<\/jats:styled-content>] 4.37 [95% confidence interval (95% CI<\/jats:styled-content>) 1.96\u20139.74]). Obese II<\/jats:styled-content> women with THR<\/jats:styled-content> also had increased risk of death before age 85 years. Women with THR<\/jats:styled-content> and WC<\/jats:styled-content> >88 cm relative to \u226488 cm had increased risk of survival to age 85 years with mobility limitation (OR<\/jats:styled-content> 1.65 [95% CI<\/jats:styled-content> 1.17\u20132.33]) but not death before age 85 years. High BMI<\/jats:styled-content>, WC<\/jats:styled-content>, and WHR<\/jats:styled-content> were associated with significantly increased risk of late\u2010life mobility limitation and death among women with TKR<\/jats:styled-content> for OA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Among older women who underwent THR<\/jats:styled-content> or TKR<\/jats:styled-content> for OA<\/jats:styled-content>, baseline general and abdominal obesity were associated with increased risk of late\u2010life mobility limitation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23438","type":"journal-article","created":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T14:52:39Z","timestamp":1507042359000},"page":"1030-1038","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["General and Abdominal Obesity as Risk Factors for Late\u2010Life Mobility Limitation After Total Knee or Hip Replacement for Osteoarthritis Among Women"],"prefix":"10.1002","volume":"70","author":[{"given":"Aladdin H.","family":"Shadyab","sequence":"first","affiliation":[{"name":"University of California San Diego School of Medicine La Jolla"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Li","sequence":"additional","affiliation":[{"name":"University of Massachusetts Medical School Worcester"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles B.","family":"Eaton","sequence":"additional","affiliation":[{"name":"Memorial Hospital of Rhode Island and Warren Alpert Medical School Brown University Pawtucket Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Z.","family":"LaCroix","sequence":"additional","affiliation":[{"name":"University of California San Diego School of Medicine La Jolla"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.44"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22721"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23888"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2008.01685.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.N.01141"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200704000-00012"},{"key":"e_1_2_6_8_1","unstructured":"US Census Bureau.National population projects: summary tables. 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