{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T21:50:27Z","timestamp":1766181027275,"version":"build-2065373602"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T00:00:00Z","timestamp":1529366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care & Research"],"published-print":{"date-parts":[[2018,8]]},"abstract":"Objective<\/jats:title>To determine the prevalence of lower urinary tract symptoms (LUTS<\/jats:styled-content>) in systemic sclerosis (SS<\/jats:styled-content>c), to find specific risk factors, and to assess their impact on quality of life (QoL).<\/jats:p><\/jats:sec>Methods<\/jats:title>In a multicenter study, 334 patients completed a self\u2010administered questionnaire on LUTS<\/jats:styled-content> and QoL. LUTS<\/jats:styled-content> were classified into 3 main categories: storage, voiding, and post\u2010micturition symptoms. Digestive symptoms burden was captured by a visual analog scale, divided into 5 equal categories. Multivariable logistic regressions were performed to test association between risk factors and LUTS<\/jats:styled-content> categories. Linear regression adjusted the association between LUTS<\/jats:styled-content> and QoL.<\/jats:p><\/jats:sec>Results<\/jats:title>LUTS<\/jats:styled-content> were recorded in 311 SS<\/jats:styled-content>c patients (96.0%) and classified as severe in 120 (38.0%). The storage category of LUTS<\/jats:styled-content> was the most prevalent (91.9%), followed by voiding (72.2%) and then by post\u2010micturition symptoms (49.8%). Risk factors identified in the multivariable models were higher than the median Health Assessment Questionnaire disability index (HAQ DI<\/jats:styled-content>; odds ratio [OR<\/jats:styled-content>] 4.2 [95% confidence interval (95% CI<\/jats:styled-content>) 1.4\u201312.9]) in the storage category; higher than the median HAQ DI<\/jats:styled-content> (OR<\/jats:styled-content> 2.4 [95% CI<\/jats:styled-content> 1.2\u20134.9]) for digestive symptoms burden (OR<\/jats:styled-content> 1.9 [95% CI<\/jats:styled-content> 1.3\u20132.7]) and synovitis (OR<\/jats:styled-content> 4.8 [95% CI<\/jats:styled-content> 1.0\u201322.6) in the voiding category; and higher for digestive symptoms burden (OR<\/jats:styled-content> 1.2 [95% CI<\/jats:styled-content> 1.0\u20131.5]) in the post\u2010micturition category of symptoms. These factors also increased the odds of having further severe symptoms. QoL was affected by the 3 categories of LUTS<\/jats:styled-content> and decreased progressively with increasing frequency of symptoms.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Self\u2010reported LUTS<\/jats:styled-content> are among the most frequent symptoms in SS<\/jats:styled-content>c and are associated with digestive symptoms. SS<\/jats:styled-content>c patients with LUTS<\/jats:styled-content> have lower QoL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23454","type":"journal-article","created":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T15:32:37Z","timestamp":1509031957000},"page":"1218-1227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence and Disease\u2010Specific Risk Factors for Lower Urinary Tract Symptoms in Systemic Sclerosis: An International Multicenter Study"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1548-7339","authenticated-orcid":false,"given":"Gregor","family":"John","sequence":"first","affiliation":[{"name":"H\u00f4pital Neuch\u00e2telois, La Chaux\u2010de\u2010Fonds, Switzerland, and Geneva University Hospitals Geneva 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