{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:43:08Z","timestamp":1793367788541,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T00:00:00Z","timestamp":1531353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000980","name":"Arthritis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000980","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32\u2010GM\u2010075766\u201009"],"award-info":[{"award-number":["T32\u2010GM\u2010075766\u201009"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010AR\u2010059\u2010703"],"award-info":[{"award-number":["R01\u2010AR\u2010059\u2010703"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008273","name":"Novartis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001831","name":"Technische Universiteit Delft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001831","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To develop standardized treatment regimens for chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO), to enable comparative effectiveness treatment studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Virtual and face\u2010to\u2010face discussions and meetings were held within the CNO\/CRMO subgroup of the Childhood Arthritis and Rheumatology Research Alliance (CARRA). A literature search was conducted, and CARRA membership was surveyed to evaluate available treatment data and identify current treatment practices. Nominal group technique was used to achieve consensus on treatment plans for CNO refractory to nonsteroidal antiinflammatory drug (NSAID) monotherapy and\/or with active spinal lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three consensus treatment plans (CTPs) were developed for the first 12 months of therapy for CNO patients refractory to NSAID monotherapy and\/or with active spinal lesions. The 3 CTPs are methotrexate or sulfasalazine, tumor necrosis factor inhibitors with optional methotrexate, and bisphosphonates. Short courses of glucocorticoids and continuation of NSAIDs are permitted for all regimens. Consensus was achieved on these CTPs among CARRA members. Consensus was also reached on subject eligibility criteria, initial evaluations that should be conducted prior to the initiation of CTPs, and data items to collect to assess treatment response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Three consensus treatment plans were developed for pediatric patients with CNO refractory to NSAIDs and\/or with active spinal lesions. Use of these CTPs will provide additional information on efficacy and will generate meaningful data for comparative effectiveness research in CNO.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23462","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T12:06:37Z","timestamp":1510056397000},"page":"1228-1237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":206,"title":["Consensus Treatment Plans for Chronic Nonbacterial Osteomyelitis Refractory to Nonsteroidal Antiinflammatory Drugs and\/or With Active Spinal Lesions"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3618-1379","authenticated-orcid":false,"given":"Yongdong","family":"Zhao","sequence":"first","affiliation":[{"name":"Seattle Children's Hospital University of Washington Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline Y.","family":"Wu","sequence":"additional","affiliation":[{"name":"University of North Carolina Chapel Hill"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa S.","family":"Oliver","sequence":"additional","affiliation":[{"name":"Stanford Children's Health Stanford University Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley M.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Children's Mercy Kansas City Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2869-1037","authenticated-orcid":false,"given":"Matthew L.","family":"Basiaga","sequence":"additional","affiliation":[{"name":"Seattle Children's Hospital University of Washington Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal S.","family":"Vora","sequence":"additional","affiliation":[{"name":"Levine Children's Hospital Charlotte North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzielan C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Stanford Children's Health Stanford University Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Fox","sequence":"additional","affiliation":[{"name":"Children's Mercy Kansas City Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Amarilyo","sequence":"additional","affiliation":[{"name":"Schneider Children's Medical Center of Israel, Petach Tikva Israel, and Sackler Faculty of Medicine, Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara M.","family":"Stern","sequence":"additional","affiliation":[{"name":"University of Utah Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Dvergsten","sequence":"additional","affiliation":[{"name":"Duke Children's Hospital Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen A.","family":"Haines","sequence":"additional","affiliation":[{"name":"Joseph M. 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