{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:42:07Z","timestamp":1788352927107,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T00:00:00Z","timestamp":1530144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011110","name":"UCB","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011110","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Comorbidities add to the burden of disease and its complexity, and may prevent the achievement of treat\u2010to\u2010target goals. The objective of this study was to study the relationship between comorbidities and key disease outcomes in spondyloarthritis (SpA), namely function, work ability, and quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients from the multinational (22 countries), cross\u2010sectional Assessment in SpondyloArthritis international Society (<jats:styled-content style=\"fixed-case\">ASAS<\/jats:styled-content>) Comorbidities in Spondyloarthritis study were included in the analysis, provided they fulfilled the <jats:styled-content style=\"fixed-case\">ASAS<\/jats:styled-content> criteria. Data on comorbidities based on both self\u2010 and physician\u2010report were collected through questionnaires and were subsequently used to compute the Rheumatic Disease Comorbidity Index (<jats:styled-content style=\"fixed-case\">RDCI<\/jats:styled-content>). Univariable and multivariable (adjusted for relevant confounders) multilevel (with country as a random effect) linear or logistic (as appropriate) regression analyses were conducted to investigate the relationship between the <jats:styled-content style=\"fixed-case\">RDCI<\/jats:styled-content> and functional ability, work ability, and quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 3,370 of 3,984 recruited patients (85%) fulfilled the <jats:styled-content style=\"fixed-case\">ASAS<\/jats:styled-content> criteria: 66% were male, mean \u00b1 <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> age was 43 \u00b1 14 years, mean \u00b1 <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> disease duration was 8.4 \u00b1 9.5 years, and mean \u00b1 <jats:styled-content style=\"fixed-case\">SD RDCI<\/jats:styled-content> was 0.7 \u00b1 1.1. At least 1 comorbidity was reported in 51% of patients; 9% had \u22653 comorbidities. <jats:styled-content style=\"fixed-case\">RDCI<\/jats:styled-content> was independently associated with a higher Bath Ankylosing Spondylitis Functional Index score (\u03b2 = 0.37, 95% confidence interval [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 0.30, 0.43), lower EuroQol 5\u2010domain questionnaire (\u03b2 = \u22120.03, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u22120.04, \u22120.02), less work employment (odds ratio [OR] 0.83, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.76, 0.91), higher absenteeism (OR 1.18, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.04, 1.34), and higher presenteeism (OR 1.42, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.26, 1.61).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Comorbidities in SpA adversely influence physical function, work ability, and quality of life and are important to take into account in daily clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23468","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T15:06:36Z","timestamp":1510326396000},"page":"1257-1262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Association of Comorbidities in Spondyloarthritis With Poor Function, Work Disability, and Quality of Life: Results From the Assessment of SpondyloArthritis International Society Comorbidities in Spondyloarthritis Study"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6847-3726","authenticated-orcid":false,"given":"E.","family":"Nikiphorou","sequence":"first","affiliation":[{"name":"Leiden University Medical Center, Leiden, The Netherlands and King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ramiro","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"van der Heijde","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Norton","sequence":"additional","affiliation":[{"name":"King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Molt\u00f3","sequence":"additional","affiliation":[{"name":"Paris Descartes University, H\u00f4pital Cochin. Assistance Publique\u2013H\u00f4pitaux de Paris, INSERM (U1153): PRES Sorbonne Paris\u2010Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Dougados","sequence":"additional","affiliation":[{"name":"Paris Descartes University, H\u00f4pital Cochin. Assistance Publique\u2013H\u00f4pitaux de Paris, INSERM (U1153): PRES Sorbonne Paris\u2010Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"van den Bosch","sequence":"additional","affiliation":[{"name":"VIB Inflammation Research Center Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Landew\u00e9","sequence":"additional","affiliation":[{"name":"Amsterdam Rheumatology Center, Amsterdam and Zuyderland MC Heerlen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Assessment of SpondyloArthritis International Society Comorbidities in Spondyloarthritis Study Task Force","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes262"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208174"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-010-1381-x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31467-2"},{"key":"e_1_2_8_6_1","first-page":"35","article-title":"Assessment of work disability in seronegative spondyloarthritis","volume":"28","author":"Rohekar S","year":"2010","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu264"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108217"},{"key":"e_1_2_8_9_1","first-page":"2281","article-title":"A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index","volume":"21","author":"Calin A","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22456"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.133488"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbr.2015.03.003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.11.004"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0836-6"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206737"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209233"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.23468","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.23468","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T14:31:54Z","timestamp":1759415514000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.23468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,28]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1002\/acr.23468"],"URL":"https:\/\/doi.org\/10.1002\/acr.23468","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,28]]},"assertion":[{"value":"2017-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}