{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T21:30:03Z","timestamp":1793568603651,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,8,12]],"date-time":"2018-08-12T00:00:00Z","timestamp":1534032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare patients with large\u2010vessel giant cell arteritis (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content>) characterized by wall thickening, stenosis, and\/or occlusion of subclavian arteries to those with subclavian dilatation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For the purposes of the present retrospective study, 2 different subsets of <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content> were identified and compared from an established cohort of patients with radiographic evidence of subclavian artery vasculitis secondary to <jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content>:<jats:styled-content style=\"fixed-case\"> LV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content> with wall thickening, stenosis, and\/or occlusion of subclavian arteries (Group 1), and <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content> with dilatation of subclavian arteries without wall thickening or stenotic changes (Group 2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 109 patients in Group 1 and 11 in Group 2. Large\u2010vessel involvement secondary to <jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content> was diagnosed significantly later in patients from Group 2 compared to those from Group 1 (median 15.3 versus 0.0 months; <jats:italic>P<\/jats:italic> = 0.010). Compared to patients from Group 1, those from Group 2 were more frequently male (17% versus 45%; <jats:italic>P<\/jats:italic> = 0.027), ever smokers (42% versus 73%; <jats:italic>P<\/jats:italic> = 0.048), and more frequently had a history of coronary artery disease (11% versus 36%; <jats:italic>P<\/jats:italic> = 0.018). At <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content> diagnosis, 10 of the 11 patients (91%) from Group 2 had aortic dilatation compared to 13 of 109 patients (12%) from Group 1 (<jats:italic>P<\/jats:italic> &lt; 0.001). During the followup period, the prevalence of aortic aneurysm was significantly higher in patients from Group 2 compared with those from Group 1 (64% versus 7% at 5 years; <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Two different subsets of <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content> were identified. Given the strong association between subclavian artery dilatation and aortic aneurysm, such patients should be evaluated and monitored carefully for aortic dilatation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23498","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T23:29:57Z","timestamp":1513812597000},"page":"1406-1411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Large\u2010Vessel Dilatation in Giant Cell Arteritis: A Different Subset of Disease?"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0362-2668","authenticated-orcid":false,"given":"Francesco","family":"Muratore","sequence":"first","affiliation":[{"name":"Azienda USL\u2010IRCCS di Reggio Emilia Reggio Emilia and University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanaz A.","family":"Kermani","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine University of California at Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia S.","family":"Crowson","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Koster","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric L.","family":"Matteson","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Salvarani","sequence":"additional","affiliation":[{"name":"Azienda USL\u2010IRCCS di Reggio Emilia Reggio Emilia and University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J.","family":"Warrington","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu329"},{"issue":"20","key":"e_1_2_6_3_1","first-page":"S43","article-title":"Imaging findings in extracranial (giant cell) temporal arteritis","volume":"18","author":"Stanson AW","year":"2000","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e318206af16"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330810"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200865"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000486"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-122-7-199504010-00004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204113"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203322"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.bor.0000197996.04709.4e"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202408"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202145"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000000381"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23577"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11453"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022694"}],"container-title":["Arthritis Care &amp; 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