{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:48:03Z","timestamp":1790419683204,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T00:00:00Z","timestamp":1536278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR46849"],"award-info":[{"award-number":["R01 AR46849"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG034676"],"award-info":[{"award-number":["R01 AG034676"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify risk factors for large\u2010joint surgery (<jats:styled-content style=\"fixed-case\">LJS<\/jats:styled-content>) versus small\u2010joint surgery (<jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>) in rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) and evaluate trends in surgery rates over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective medical record review of all orthopedic surgeries following first fulfillment of the 1987 American College of Rheumatology criteria for adult\u2010onset <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> among residents of Olmsted County, Minnesota between 1980 and 2013 was performed. Risk factors were examined using Cox models adjusted for age, sex, and calendar year of <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> incidence. Trends in incidence of joint surgeries were examined using Poisson regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1,077 patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> (mean age 56 years, 69% female, 66% seropositive for rheumatoid factor [RF] and anti\u2013cyclic citrullinated peptide [anti\u2010CCP] antibodies) were followed for a median of 10.7 years, during which 112 patients (90 women) underwent at least 1 <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content> and 204 (141 women) underwent at least 1 <jats:styled-content style=\"fixed-case\">LJS<\/jats:styled-content>. Risk factors included advanced age, and RF and anti\u2010CCP antibody positivity for both <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LJS<\/jats:styled-content>, and body mass index \u226530 kg\/m<jats:sup>2<\/jats:sup> for <jats:styled-content style=\"fixed-case\">LJS<\/jats:styled-content>. Risk factors for <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LJS<\/jats:styled-content> at any time during followup included the presence of radiographic erosions, large\u2010joint swelling, and methotrexate use. <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content> rates decreased by calendar year of incidence (hazard ratio 0.53, <jats:italic>P<\/jats:italic> = 0.001), with significant decline in <jats:styled-content style=\"fixed-case\">the rates of SJS<\/jats:styled-content> after 1995. The cumulative incidence of <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content> was higher in women than men (<jats:italic>P<\/jats:italic> = 0.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In recent years, there has been a significant decline in the rates of <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content> but not <jats:styled-content style=\"fixed-case\">LJS<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>. The incidence of <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content> is higher among women. Traditional <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> risk factors are strong predictors for <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LJS<\/jats:styled-content>. Increasing age and obesity are predictive of <jats:styled-content style=\"fixed-case\">LJS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23499","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T23:29:12Z","timestamp":1513812552000},"page":"1546-1550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Orthopedic Surgery Among Patients With Rheumatoid Arthritis: A Population\u2010Based Study to Identify Risk Factors, Sex Differences, and Time Trends"],"prefix":"10.1002","volume":"70","author":[{"given":"Michael D.","family":"Richter","sequence":"first","affiliation":[{"name":"Mayo School of Graduate Medical Education Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia S.","family":"Crowson","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine and Science Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric L.","family":"Matteson","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine and Science Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashima","family":"Makol","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine and Science Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199806)41:6<1072::AID-ART14>3.0.CO;2-G"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.111056"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.086710"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu340"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2013.810519"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2004.07.010"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208669"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38344"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140011"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130118"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0713-3"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.01.002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1186\/ar2591","article-title":"Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST\u2010RA study","volume":"11","author":"Sokka T","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0115"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140658"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.23499","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.23499","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T15:18:33Z","timestamp":1759418313000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.23499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,7]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1002\/acr.23499"],"URL":"https:\/\/doi.org\/10.1002\/acr.23499","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,7]]},"assertion":[{"value":"2017-08-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}