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Global disease activity (Systemic Lupus Erythematosus Disease [SLE] Activity Index 2000), damage scores (<jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content> International Collaborating Clinics\/American College of Rheumatology Damage Index), and Short Form 36 (<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201036) scores were collected. Time to event, linear and logistic regressions, and multistate models were used as appropriate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cer<jats:styled-content style=\"fixed-case\">VE<\/jats:styled-content>s were the fourth most frequent <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> event: 82 of 1,826 patients had 109 events; of these events, 103 were attributed to <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>, and 44 were identified at the time of enrollment. The predominant events were stroke (60 of 109 patients) and transient ischemia (28 of 109 patients). Cer<jats:styled-content style=\"fixed-case\">VE<\/jats:styled-content>s were associated with other <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> events attributed to <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>, non\u2013<jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>\u2010attributed <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> events, African ancestry (at <jats:styled-content style=\"fixed-case\">US SLICC<\/jats:styled-content> sites), and increased organ damage scores. Lupus anticoagulant increased the risk of first stroke and sinus thrombosis and transient ischemic attack. Physician assessment indicated resolution or improvement in the majority of patients, but patients reported sustained reduction in <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201036 summary and subscale scores following a Cer<jats:styled-content style=\"fixed-case\">VE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cer<jats:styled-content style=\"fixed-case\">VE<\/jats:styled-content>s, the fourth most frequent <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> event in <jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>, are usually attributable to lupus. 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