{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:37:15Z","timestamp":1787611035398,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012665","name":"Institute for Clinical Evaluative Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000226","name":"Ontario Ministry of Health and Long-Term Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare mortality rates, underlying causes of death, excess mortality, and years of potential life lost (<jats:styled-content style=\"fixed-case\">YPLL<\/jats:styled-content>) among patients with rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) relative to the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied an inception cohort of 87,114 Ontario\u2010based <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients and 348,456 age\/sex\/area\u2010matched general population comparators from years 2000 to 2013. All\u2010cause, cause\u2010specific, and excess mortality rates, mortality rate ratios (<jats:styled-content style=\"fixed-case\">MRR<\/jats:styled-content>s), and the <jats:styled-content style=\"fixed-case\">YPLL<\/jats:styled-content> were estimated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 11,778 <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients (14%) and 32,472 comparators (9%) died during 508,385 and 1,769,365 patient\u2010years of follow\u2010up, respectively, for corresponding mortality rates of 232 (95% confidence interval [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 228\u2013236) and 184 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 182\u2013186) per 10,000 patient\u2010years. The leading causes of death in both groups were diseases of the circulatory system, cancer, and respiratory conditions. Increased mortality for all\u2010cause and specific causes was observed in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients relative to the general population. <jats:styled-content style=\"fixed-case\">MRR<\/jats:styled-content>s were elevated for most causes of death. Age\u2010specific mortality ratios illustrated a high excess mortality among <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients &lt;45 years of age for respiratory disease and circulatory disease. The <jats:styled-content style=\"fixed-case\">YPLL<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients was 7,436 per 10,000 persons, compared with 4,083 <jats:styled-content style=\"fixed-case\">YPLL<\/jats:styled-content> among those without <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among most causes of death, mortality rates were increased in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients relative to the general population. The potential life years lost (before the age of 75 years) among <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients was roughly double that among those without <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>, reflecting higher rate ratios for most causes of death and <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients dying at earlier ages.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23548","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T01:50:48Z","timestamp":1520387448000},"page":"1748-1755","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["Causes of Death in Rheumatoid Arthritis: How Do They Compare to the General Population?"],"prefix":"10.1002","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7464-0460","authenticated-orcid":false,"given":"Jessica","family":"Widdifield","sequence":"first","affiliation":[{"name":"Sunnybrook Research Institute, Toronto, Ontario, Canada McGill University, Montreal, Quebec Research Institute of the McGill University Health Centre, Montreal, Quebec Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada and University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5995-1714","authenticated-orcid":false,"given":"J. 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