{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:40:56Z","timestamp":1791308456017,"version":"4.3.1"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T00:00:00Z","timestamp":1541116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Ministry of Health"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care & Research"],"published-print":{"date-parts":[[2018,12]]},"abstract":"\n Objective<\/jats:title>\n \n To assess potential associations among serum cytokines and micro\n RNA<\/jats:styled-content>\n (miR) levels with ultrasound (\n US<\/jats:styled-content>\n ) findings suggestive of urate deposits in chronic asymptomatic hyperuricemia and gout.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n All participants underwent musculoskeletal\n US<\/jats:styled-content>\n and measurements of serum interleukin\u20101\u03b2 (\n IL<\/jats:styled-content>\n \u20101\u03b2),\n IL<\/jats:styled-content>\n \u20102,\n IL<\/jats:styled-content>\n \u20104,\n IL<\/jats:styled-content>\n \u20105,\n IL<\/jats:styled-content>\n \u20106,\n IL<\/jats:styled-content>\n \u20108,\n IL<\/jats:styled-content>\n \u201010,\n IL<\/jats:styled-content>\n \u201012,\n IL<\/jats:styled-content>\n \u201013, interferon\u2010\u03b3, tumor necrosis factor, monocyte chemoattractant protein 1, and epithelial neutrophil\u2013activating peptide 78, as well as miR\u2010146a, miR\u2010155, and miR\u2010223 levels.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Thirty individuals with asymptomatic hyperuricemia, 31 normouricemic controls, and 30 patients with gout were included. The frequency of synovitis and double contour sign using\n US<\/jats:styled-content>\n was similar between asymptomatic hyperuricemia (67% and 27%, respectively) and patients with gout (77% and 27%, respectively), and each had a higher frequency than controls (45% and 0%, respectively). Serum\n IL<\/jats:styled-content>\n \u20106 and\n IL<\/jats:styled-content>\n \u20108 levels were similar between patients with asymptomatic hyperuricemia (mean \u00b1\n SD<\/jats:styled-content>\n 69.7 \u00b1 73.4 and 18.5 \u00b1 25.6 pg\/ml, respectively) and gout (mean \u00b1\n SD<\/jats:styled-content>\n 75.8 \u00b1 47.6 and 24.4 \u00b1 31.7 pg\/ml, respectively), and higher than controls (mean \u00b1\n SD<\/jats:styled-content>\n 28.2 \u00b1 17.6 and 7.4 \u00b1 6.0 pg\/ml, respectively). A similar distribution was observed for miR\u2010155 levels in asymptomatic hyperuricemia, patients with gout, and controls (mean \u00b1\n SD<\/jats:styled-content>\n 0.22 \u00b1 0.18, 0.20 \u00b1 0.14, and 0.08 \u00b1 0.04, respectively). Associations between morphostructural abnormalities suggestive of urate deposits (regardless of clinical diagnosis) and serum markers were assessed. Subjects with urate deposits had higher\n IL<\/jats:styled-content>\n \u20106 (257.2 versus 47.0 pg\/ml;\n P<\/jats:italic>\n = 0.005),\n IL<\/jats:styled-content>\n \u20108 (73.2 versus 12.0 pg\/ml;\n P<\/jats:italic>\n = 0.026), and miR\u2010155 (0.21 versus 0.16;\n P<\/jats:italic>\n = 0.015) levels than those without deposition findings.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In individuals with chronic asymptomatic hyperuricemia, the presence of synovitis and double contour sign by\n US<\/jats:styled-content>\n may represent a subclinical manifestation of monosodium urate crystal nucleation, capable of triggering inflammatory pathways (\n IL<\/jats:styled-content>\n \u20106 and\n IL<\/jats:styled-content>\n \u20108) and mechanisms of intercellular communication (miR\u2010155), similar to what is observed in patients with gout.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/acr.23549","type":"journal-article","created":{"date-parts":[[2018,2,18]],"date-time":"2018-02-18T20:32:44Z","timestamp":1518985964000},"page":"1814-1821","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Levels of Cytokines and Micro\n RNA<\/scp>\n s in Individuals With Asymptomatic Hyperuricemia and Ultrasonographic Findings of Gout: A Bench\u2010to\u2010Bedside Approach"],"prefix":"10.1002","volume":"70","author":[{"given":"Irving O.","family":"Estevez\u2010Garcia","sequence":"first","affiliation":[{"name":"Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selma","family":"Gallegos\u2010Nava","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Rehabilitaci\u00f3n Luis Guillermo Ibarra Ibarra Hospital General Dr. Dar\u00edo Fern\u00e1ndez Fierro, and Instituto de Seguridad y 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