{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T05:10:34Z","timestamp":1772601034163,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T00:00:00Z","timestamp":1548720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008272","name":"Novartis Pharmaceuticals Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007827","name":"American College of Gastroenterology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL\u20101TR\u2010001881"],"award-info":[{"award-number":["UL\u20101TR\u2010001881"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Few studies have examined ankylosing spondylitis (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>) patients\u2019 concerns about and perceptions of biologic therapies, apart from traditional surveys. In this study, we used social media data to examine the knowledge, attitudes, and beliefs of <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> patients regarding biologic therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected posts published on 601 social media sites between January 1, 2016 and April 26, 2017. In each post, both an <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> keyword and a biologic were mentioned. To explore themes within the collection of posts in an unsupervised manner, a latent Dirichlet allocation topic model was fit to the data set. Each discovered topic was represented as a discrete distribution over the words in the collection, similar to a word cloud. The topics were manually reviewed to identify themes, which were confirmed using thematic data analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We examined 27,416 social media posts and identified 112 themes. The majority of themes (n = 67 [60%]) focused on discussions related to <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> treatment. Other themes, including the psychological impact of <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>, reporting of medical literature, and <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> disease consequences, accounted for the remaining 40% (n = 45). In discussions regarding <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> treatment, most topics involved biologics, and most subthemes involved side effects (e.g., fatigue, allergic reactions), biologic treatment attributes (e.g., dosing, frequency), and concerns about use of biologics (e.g., increased cancer risk). Additional implicit patient needs (e.g., support) were identified using qualitative analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Social media revealed a dynamic range of themes governing <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> patients\u2019 experience with and choice of biologic agents. The complexity of selecting biologics from among many such agents and navigating their risk\/benefit profiles suggests the merit of creating online tools tailored to support patients\u2019 decision\u2010making with regard to biologic therapies for <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23600","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T07:16:50Z","timestamp":1526887010000},"page":"323-330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Patient Concerns and Perceptions Regarding Biologic Therapies in Ankylosing Spondylitis: Insights From a Large\u2010Scale Survey of Social Media Platforms"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3248-5327","authenticated-orcid":false,"given":"Eldin","family":"Dzubur","sequence":"first","affiliation":[{"name":"Cedars\u2010Sinai Medical Center  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5071-0500","authenticated-orcid":false,"given":"Carine","family":"Khalil","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Medical Center and Cedars\u2010Sinai Center for Outcomes Research and Education  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0664-9479","authenticated-orcid":false,"given":"Christopher V.","family":"Almario","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Medical Center and Cedars\u2010Sinai Center for Outcomes Research and Education  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1730-9616","authenticated-orcid":false,"given":"Benjamin","family":"Noah","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Medical Center and Cedars\u2010Sinai Center for Outcomes Research and Education  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deeba","family":"Minhas","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Medical Center  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Ishimori","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Medical Center  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4119-8143","authenticated-orcid":false,"given":"Corey","family":"Arnold","sequence":"additional","affiliation":[{"name":"Medical Imaging Informatics University of California  Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0463-4329","authenticated-orcid":false,"given":"Yujin","family":"Park","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals Corporation  East Hanover New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8970-4260","authenticated-orcid":false,"given":"Jonathan","family":"Kay","sequence":"additional","affiliation":[{"name":"University of Massachusetts Memorial Medical Center and University of Massachusetts Medical School  Worcester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5568-388X","authenticated-orcid":false,"given":"Michael H.","family":"Weisman","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Medical Center  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4608-6896","authenticated-orcid":false,"given":"Brennan M. 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