{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:51:26Z","timestamp":1768315886327,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T00:00:00Z","timestamp":1549238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000106","name":"Saskatchewan Health Research Foundation","doi-asserted-by":"publisher","award":["New Investigator Establishment Grant"],"award-info":[{"award-number":["New Investigator Establishment Grant"]}],"id":[{"id":"10.13039\/501100000106","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care & Research"],"published-print":{"date-parts":[[2019,3]]},"abstract":"Objective<\/jats:title>To estimate the incidence and prevalence of juvenile idiopathic arthritis (JIA<\/jats:styled-content>) in children ages <16 years in the province of Manitoba, Canada, and to determine changes in estimates between 2000 and 2012.<\/jats:p><\/jats:sec>Methods<\/jats:title>JIA<\/jats:styled-content> cases were ascertained from the administrative health data of Manitoba, using a validated case\u2010finding algorithm. Annual incidence and prevalence rates were estimated using a generalized linear model with generalized estimating equations (GEE<\/jats:styled-content>s), adjusting for sociodemographic characteristics. Changes in estimates were tested using piecewise regression models.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 455 cases of JIA<\/jats:styled-content> prevalence met the inclusion criteria. Sex\u2010 and age\u2010adjusted incidence estimates were 14.01 (95% confidence interval [95% CI<\/jats:styled-content>] 13.52, 14.53) in 2000\/2001 and 9.18 (95% CI<\/jats:styled-content> 8.56, 9.85) in 2010\/2011. Prevalence estimates were 65.33 (95% CI<\/jats:styled-content> 63.87, 66.83) in 2000\/2001 and 59.61 (95% CI<\/jats:styled-content> 58.17, 61.08) in 2010\/2011. A linear piecewise model provided the best fit to the data. There was a significant decrease in prevalence over the study period (\u20130.18 [95% CI<\/jats:styled-content> \u20130.35, \u20130.02]; P<\/jats:italic> = 0.0292) but no statistically significant change in incidence (\u20130.46 [95% CI<\/jats:styled-content> \u20130.94, 0.01]; P<\/jats:italic> = 0.0571). Sex\u2010stratified models revealed a decrease for males in both prevalence (estimate \u20130.54 [95% CI<\/jats:styled-content> \u20130.84, \u201310.25]; P<\/jats:italic> = 0.0003) and incidence (estimate \u20131.02 [95% CI<\/jats:styled-content> \u20132.02, \u20130.04]; P<\/jats:italic> = 0.0439); there were no changes for females.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Few population\u2010based longitudinal epidemiologic studies of JIA<\/jats:styled-content> have been conducted. Our findings suggested a decrease in overall JIA<\/jats:styled-content> prevalence, and in incidence and prevalence in men. Further research to validate these findings in other cohorts and to explore factors that contribute to this change will benefit future health care planning for JIA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23606","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T08:37:07Z","timestamp":1527237427000},"page":"413-418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Trends in Population\u2010Based Incidence and Prevalence of Juvenile Idiopathic Arthritis in Manitoba, Canada"],"prefix":"10.1002","volume":"71","author":[{"given":"Natalie J.","family":"Shiff","sequence":"first","affiliation":[{"name":"University of Florida Gainesville and University of Saskatchewan Saskatoon Saskatchewan Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiem","family":"Oen","sequence":"additional","affiliation":[{"name":"University of Manitoba Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine","family":"Kroeker","sequence":"additional","affiliation":[{"name":"University of Manitoba Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Lix","sequence":"additional","affiliation":[{"name":"University of Manitoba Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2013.09.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-017-3734-1"},{"key":"e_1_2_7_4_1","unstructured":"World Health Organization.International Classification of Diseases Eleventh Revision. 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Aboriginal Statistics at a Glance. Census Highlight Tables. Population Counts.http:\/\/www12.statcan.ca\/census-recensement\/2006\/dp-pd\/hlt\/97-558\/pages\/page.cfm?Lang=E&Geo=PR&Code=01&Table=1&Data=Count&Sex=1&Age=1&StartRec=1&Sort=2&Display=Page."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/40.8.928"},{"issue":"2","key":"e_1_2_7_17_1","first-page":"195","article-title":"Current proposed revision of JRA criteria","volume":"20","author":"Brewer EJ","year":"1977","journal-title":"Arthritis Rheum"}],"container-title":["Arthritis Care & Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.23606","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.23606","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acr.23606","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.23606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T17:33:29Z","timestamp":1759426409000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.23606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,4]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/acr.23606"],"URL":"https:\/\/doi.org\/10.1002\/acr.23606","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,4]]},"assertion":[{"value":"2017-12-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}