{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T08:10:38Z","timestamp":1780733438663,"version":"3.54.1"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T00:00:00Z","timestamp":1556755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008209","name":"Robert Wehnerts og Kirsten Wehnerts Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008209","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the prognostic value of widespread pain and of musculoskeletal ultrasound (US) examination for subsequent treatment outcomes in patients with psoriatic arthritis (PsA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An exploratory prospective cohort study enrolled patients with PsA initiating biologic or conventional synthetic disease\u2010modifying antirheumatic drugs in routine care. Clinical, US, and patient\u2010reported measures were collected at baseline and after 4 months. Widespread nonarthritic pain (WP) was defined as a Widespread Pain Index score of \u22654 with pain in \u22654 of 5 regions. PsA activity by US was defined as color Doppler (yes\/no) in selected entheses, joints, or tendons. The main response criteria included the American College of Rheumatology 20% improvement, the Disease Activity in Psoriatic Arthritis 50% improvement, and minimal disease activity. The primary analyses were age\u2010 and sex\u2010adjusted logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>WP was present in 24 of 69 included patients (35%) and was associated with worse patient\u2010reported and composite baseline measures, while US and other objective findings were similar to those in patients without WP. The odds of reaching minimal disease activity after 4 months were significantly greater for patients enrolled without WP (odds ratio 18.43 [95% confidence interval 1.51, 224.41]; <jats:italic>P<\/jats:italic> = 0.022), while WP did not impair other response measures. Patients with baseline color Doppler activity (n = 42 [61%]) had a worse objective PsA burden, but their chance of treatment response was comparable to those without color Doppler.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>More than one\u2010third of patients with PsA presented with WP, which was associated with worse patient\u2010reported scores and failure to achieve minimal disease activity following conventional synthetic or biologic disease\u2010modifying antirheumatic drug therapy. PsA activity by color Doppler US had no influence on subsequent treatment response in this PsA cohort.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23693","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T06:17:46Z","timestamp":1530771466000},"page":"798-810","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Pain Mechanisms and Ultrasonic Inflammatory Activity as Prognostic Factors in Patients With Psoriatic Arthritis: A Prospective Cohort Study"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8046-263X","authenticated-orcid":false,"given":"Pil","family":"H\u00f8jgaard","sequence":"first","affiliation":[{"name":"The Parker Institute, Bispebjerg and Frederiksberg Hospital, Frederiksberg, and Rigshospitalet Gentofte  Hellerup 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and Frederiksberg Hospital, Frederiksberg, and Rigshospitalet Gentofte  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Ballegaard","sequence":"additional","affiliation":[{"name":"The Parker Institute, Bispebjerg and Frederiksberg Hospital, Frederiksberg, and Rigshospitalet Gentofte  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Dreyer","sequence":"additional","affiliation":[{"name":"The Parker Institute, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Rigshospitalet Gentofte, Hellerup, and Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Mease","sequence":"additional","affiliation":[{"name":"Swedish Medical Center University of Washington  Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"de Wit","sequence":"additional","affiliation":[{"name":"Vrije 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