{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:55:05Z","timestamp":1793148905316,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008368","name":"Gigtforeningen","doi-asserted-by":"publisher","award":["R100\u2010A2156"],"award-info":[{"award-number":["R100\u2010A2156"]}],"id":[{"id":"10.13039\/100008368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008368","name":"Gigtforeningen","doi-asserted-by":"publisher","award":["R101\u2010A2035"],"award-info":[{"award-number":["R101\u2010A2035"]}],"id":[{"id":"10.13039\/100008368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","award":["2014"],"award-info":[{"award-number":["2014"]}],"id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007405","name":"Hjerteforeningen","doi-asserted-by":"publisher","award":["12\u201004\u2010R91\u2010A3797"],"award-info":[{"award-number":["12\u201004\u2010R91\u2010A3797"]}],"id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010078","name":"Region Midtjylland","doi-asserted-by":"publisher","award":["2012"],"award-info":[{"award-number":["2012"]}],"id":[{"id":"10.13039\/501100010078","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care & Research"],"published-print":{"date-parts":[[2019,6]]},"abstract":"Objective<\/jats:title>To investigate the relationship between bioimpedance\u2010derived total body fat percentage, waist circumference, and body mass index (BMI<\/jats:styled-content>) and the subsequent development of rheumatoid arthritis (RA<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>A population\u2010based prospective cohort study was conducted using 55,037 patients enrolled in the Danish Diet, Cancer, and Health cohort. Baseline data included anthropometric measures and lifestyle factors. Individuals who developed RA<\/jats:styled-content> were identified through linkage with the Danish National Patient Registry. The relationships between bioimpedance\u2010derived body fat percentage, waist circumference, and BMI<\/jats:styled-content> and incident RA<\/jats:styled-content> were assessed using Cox proportional hazards regression models, stratifying by sex. All analyses were performed for overall RA<\/jats:styled-content> and the serologic subtypes seropositive and other RA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 210 men (37.6% with seropositive RA<\/jats:styled-content>) and 456 women (41.0% with seropositive RA<\/jats:styled-content>) developed RA<\/jats:styled-content> during a median follow\u2010up of 20.1 years. In women, the overall RA<\/jats:styled-content> risk was 10% higher for each 5% increment of total body fat (hazard ratio [HR<\/jats:styled-content>] 1.10 [95% confidence interval (95% CI<\/jats:styled-content>) 1.02\u20131.18]), 5% higher for each 5\u2010cm increment of waist circumference (HR<\/jats:styled-content> 1.05 [95% CI<\/jats:styled-content> 1.01\u20131.10]), and nearly 50% higher in those whose BMI<\/jats:styled-content> was in the obese range compared to normal range BMI<\/jats:styled-content> (HR<\/jats:styled-content> 1.46 [95% CI<\/jats:styled-content> 1.12\u20131.90]). These positive associations were also found for patients with other RA<\/jats:styled-content>. In men, there were no clear associations between body fat percentage, waist circumference, or BMI<\/jats:styled-content> and RA<\/jats:styled-content>. No significant associations were found for seropositive RA<\/jats:styled-content> in women or men, possibly related to low sample size.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In women, higher body fat percentage, higher waist circumference, and obesity were associated with a higher risk of RA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23694","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T06:20:24Z","timestamp":1530771624000},"page":"777-786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Body Fat Percentage, Waist Circumference, and Obesity As Risk Factors for Rheumatoid Arthritis: A Danish Cohort Study"],"prefix":"10.1002","volume":"71","author":[{"given":"Asta","family":"Linauskas","sequence":"first","affiliation":[{"name":"Aarhus University Hospital, Aarhus, and North Denmark Regional Hospital Hjoerring Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Overvad","sequence":"additional","affiliation":[{"name":"Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Symmons","sequence":"additional","affiliation":[{"name":"University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin B.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Stengaard\u2010Pedersen","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital and Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"de Thurah","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital and Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.12.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.096487"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker299"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes376"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2012.723744"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203338"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.90"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0290072"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(03)00132-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199007000-00005"},{"key":"e_1_2_7_12_1","first-page":"525","article-title":"Smoking, obesity, alcohol consumption, and the risk of rheumatoid arthritis","volume":"5","author":"Voigt LF","year":"1994","journal-title":"Epidemiology"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780401106"},{"key":"e_1_2_7_14_1","first-page":"47","article-title":"Current tobacco smoking, formal education, and the risk of rheumatoid arthritis","volume":"26","author":"Uhlig T","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_7_15_1","first-page":"246","article-title":"Blood transfusion, alcohol use, and anthropometric risk factors for rheumatoid arthritis in older women","volume":"29","author":"Cerhan JR","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2022"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740802448825"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21660"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202254"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21749"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205459"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu045"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202481"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev313"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2010.5"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033308"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.11"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2004.09.012"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1550-8528.1999.tb00404.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802695"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032213"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117900"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq190"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/14034940601047986"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810393562"},{"key":"e_1_2_7_36_1","first-page":"441","article-title":"The Danish Civil Registration System: a cohort of eight million persons","volume":"53","author":"Pedersen CB","year":"2006","journal-title":"Dan Med Bull"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811401482"},{"key":"e_1_2_7_38_1","unstructured":"World Health Organization.Classification of diseases. URL:http:\/\/www.who.int\/classifications\/icd\/en\/."},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394717"},{"key":"e_1_2_7_40_1","volume-title":"International standards for anthropometric assessment","author":"Marfell\u2010Jones M","year":"2001"},{"key":"e_1_2_7_41_1","first-page":"789","article-title":"Prediction of body water and fat in adult Danes from measurement of electrical impedance: a validation study","volume":"14","author":"Heitmann BL","year":"1990","journal-title":"Int J Obes"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S175406"},{"key":"e_1_2_7_43_1","unstructured":"World Health Organization Centre for Drug Statistics Methodology.Structure and principles. URL:https:\/\/www.whocc.no\/atc\/structure_and_principles\/."},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/20.4.906"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/20.4.900"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009034"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/64.4.650"},{"key":"e_1_2_7_48_1","volume-title":"Report of a WHO expert consultation: Geneva, 8\u201311 December 2008","author":"Waist circumference and waist\u2010hip ratio","year":"2011"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960130809"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi008"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3360"}],"container-title":["Arthritis Care & Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.23694","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.23694","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acr.23694","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.23694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T17:32:57Z","timestamp":1759426377000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.23694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,23]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1002\/acr.23694"],"URL":"https:\/\/doi.org\/10.1002\/acr.23694","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,23]]},"assertion":[{"value":"2018-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}