{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:41:07Z","timestamp":1789382467852,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["K2014\u201052X\u201014045\u201014\u20103"],"award-info":[{"award-number":["K2014\u201052X\u201014045\u201014\u20103"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the occurrence of ischemic stroke and hemorrhagic stroke in patients with idiopathic inflammatory myopathies (<jats:styled-content style=\"fixed-case\">IIM<\/jats:styled-content>s) compared to that in the general population and to investigate how it varies by sex, age, clinical subdiagnosis, and time since <jats:styled-content style=\"fixed-case\">IIM<\/jats:styled-content> diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients in Sweden with newly diagnosed <jats:styled-content style=\"fixed-case\">IIM<\/jats:styled-content> were identified from the National Patient Register, and general population comparators were identified from the Total Population Register. The study population was followed prospectively until death, emigration, December 2013, or first incident stroke. Incidence rates, rate differences, and hazard ratios (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>s) comparing patients with <jats:styled-content style=\"fixed-case\">IIM<\/jats:styled-content>s to the general population were estimated and stratified by age, sex, type of <jats:styled-content style=\"fixed-case\">IIM<\/jats:styled-content>, and time since diagnosis. To account for the competing risk of death, the subdistribution <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> was estimated using Fine and Gray models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed 34 and 229 stroke events in 663 <jats:styled-content style=\"fixed-case\">IIM<\/jats:styled-content> patients and 6,673 comparators, respectively. The <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> was elevated for ischemic stroke (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 2.1 [95% confidence interval (95% CI) 1.4, 3.0]). Few hemorrhagic stroke events were identified, but an increased risk was observed (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.9 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.7, 5.5]). The association remained elevated for both outcomes when taking the competing risk of death into account. For ischemic stroke, the rate difference was highest in the oldest age group (\u226568 years), while the <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> was highest in the youngest age group (&lt;56 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that the risk of both ischemic stroke and hemorrhagic stroke is increased in patients with <jats:styled-content style=\"fixed-case\">IIM<\/jats:styled-content>s, but it should be kept in mind that stroke is a rare event. Focus on prevention should be directed toward groups with the highest absolute risk, especially older patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23702","type":"journal-article","created":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T07:08:36Z","timestamp":1531379316000},"page":"970-976","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Risk of Ischemic and Hemorrhagic Stroke in Patients With Idiopathic Inflammatory Myopathies: A Swedish Population\u2010Based Cohort Study"],"prefix":"10.1002","volume":"71","author":[{"given":"John","family":"Moshtaghi\u2010Svensson","sequence":"first","affiliation":[{"name":"Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid E.","family":"Lundberg","sequence":"additional","affiliation":[{"name":"Karolinska Institutet and Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Von Euler","sequence":"additional","affiliation":[{"name":"Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth V.","family":"Arkema","sequence":"additional","affiliation":[{"name":"Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8996-5260","authenticated-orcid":false,"given":"Marie","family":"Holmqvist","sequence":"additional","affiliation":[{"name":"Karolinska Institutet and Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199111213252107"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211402"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203305lu2205oa"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12245"},{"key":"e_1_2_6_6_1","first-page":"461","article-title":"Risk of myocardial infarction and ischaemic stroke in adults with polymyositis and dermatomyositis: a general population\u2010based study","volume":"55","author":"Rai SK","year":"2016","journal-title":"Rheumatology (Oxford)"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090061"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-12-41"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-014-3166-0"},{"key":"e_1_2_6_10_1","unstructured":"National Board of Health and Welfare.The National Patient Register. 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