{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:24:43Z","timestamp":1782923083375,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T00:00:00Z","timestamp":1560297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To study self\u2010reported pain early in the disease course of juvenile idiopathic arthritis (\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      ) as a predictor of long\u2010term disease outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Consecutive cases of\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      with disease onset from 1997 to 2000 from defined geographical areas of Norway, Sweden, Finland, and Denmark were prospectively enrolled in this population\u2010based cohort study. Self\u2010reported, disease\u2010related pain was measured on a 10\u2010cm visual analog scale (\n                      <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>\n                      pain). Inclusion criteria were a baseline visit with a pain score 6 months after disease onset, followed by an 8\u2010year study visit. Remission was defined according to Wallace et\u00a0al (2004) preliminary criteria. Functional disability was measured by the Childhood Health Assessment Questionnaire and the Child Health Questionnaire Parent Form if the child was age &lt;18 years and by the Health Assessment Questionnaire if age \u226518 years. Damage was scored using the Juvenile Arthritis Damage Index.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The final study cohort consisted of 243 participants, and 120 participants (49%) had oligoarticular onset. At baseline, 76% reported a\n                      <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>\n                      pain score &gt;0 compared to 57% reporting at 8 years. Half of those who reported baseline pain also reported pain at 8 years but at a lower intensity. Compared to no pain, higher pain intensity at baseline predicted more pain at 8 years, more functional disability, more damage, and less remission without medication. Baseline pain predicted more use of disease\u2010modifying antirheumatic drugs\/biologics during the disease course. Participants with oligoarticular\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      reporting pain at baseline were more likely to develop extended oligoarticular\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      or other\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      categories with an unfavorable prognosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Early self\u2010reported, disease\u2010related pain among children and adolescents with\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      is common and seems to predict persistent pain and unfavorable long\u2010term disease outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.23715","type":"journal-article","created":{"date-parts":[[2018,7,29]],"date-time":"2018-07-29T03:28:43Z","timestamp":1532834923000},"page":"961-969","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Early Self\u2010Reported Pain in Juvenile Idiopathic Arthritis as Related to Long\u2010Term Outcomes: Results From the Nordic Juvenile Idiopathic Arthritis Cohort Study"],"prefix":"10.1002","volume":"71","author":[{"given":"Ellen Dalen","family":"Arnstad","sequence":"first","affiliation":[{"name":"Levanger Hospital Nord\u2010Tr\u00f8ndelag Hospital Trust, Levanger, and Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Rypdal","sequence":"additional","affiliation":[{"name":"University Hospital of North Norway and Arctic University of Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvi","family":"Peltoniemi","sequence":"additional","affiliation":[{"name":"Hospital for Children and Adolescents University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troels","family":"Herlin","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillemor","family":"Berntson","sequence":"additional","affiliation":[{"name":"Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Fasth","sequence":"additional","affiliation":[{"name":"University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Glerup","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ekelund","sequence":"additional","affiliation":[{"name":"Uppsala University, Uppsala, and Ryhov County Hospital  Jonkoping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Zak","sequence":"additional","affiliation":[{"name":"Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristiina","family":"Aalto","sequence":"additional","affiliation":[{"name":"Hospital for Children and Adolescents University of Helsinki  Helsinki 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