{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:38:46Z","timestamp":1789151926834,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T00:00:00Z","timestamp":1562630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To study disease activity in women with peripheral psoriatic arthritis (PsA) during and after pregnancy. Previous knowledge on this topic is sparse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 108 pregnancies in 103 women with PsA from a Norwegian nationwide register. Disease activity was assessed prospectively at 7 time points before, throughout, and after pregnancy with the 3\u2010variable Disease Activity Score in 28 joints (<jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28) using C\u2010reactive protein levels and the Bath Ankylosing Spondylitis Disease Activity Index (<jats:styled-content style=\"fixed-case\">BASDAI<\/jats:styled-content>). Scores assessed at each time point were analyzed in a linear mixed model. We did additional analyses with \u201ctumor necrosis factor inhibitor (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i) in pregnancy\u201d as a covariate. The same statistical method was used to study self\u2010reported physical function, pain, and mental health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Approximately 75% of the women were in remission or had low disease activity during and after pregnancy according to the <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> score. Although disease activity was altogether stable, we found that it decreased in pregnancy and increased within 6 months postpartum. Disease activity at 6 months postpartum was significantly higher than at 6 weeks postpartum (mean <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> score 2.71 versus 2.45; <jats:italic>P<\/jats:italic> = 0.016). Women using <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i in pregnancy had significantly lower disease activity than women not using <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i (mean <jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> score at 6 months postpartum 2.22 versus 2.72; <jats:italic>P<\/jats:italic> = 0.043). <jats:styled-content style=\"fixed-case\">BASDAI<\/jats:styled-content> scores were also low and stable during pregnancy but significantly higher at 6 months postpartum than at 6 weeks postpartum (mean <jats:styled-content style=\"fixed-case\">BASDAI<\/jats:styled-content> score 3.69 versus 2.95; <jats:italic>P<\/jats:italic> = 0.013).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Studying women with PsA, we found that disease activity was highest at 6 months postpartum but altogether low and stable in the period from planning pregnancy to 1 year after delivery. Women using <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>i in pregnancy had significantly lower disease activity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23747","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T05:42:05Z","timestamp":1536298925000},"page":"1092-1100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Psoriatic Arthritis Disease Activity During and After Pregnancy: A Prospective Multicenter Study"],"prefix":"10.1002","volume":"71","author":[{"given":"Kristin","family":"Ursin","sequence":"first","affiliation":[{"name":"Trondheim University Hospital and Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stian","family":"Lydersen","sequence":"additional","affiliation":[{"name":"Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan F.","family":"Skomsvoll","sequence":"additional","affiliation":[{"name":"Trondheim University Hospital  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Wallenius","sequence":"additional","affiliation":[{"name":"Trondheim University Hospital and Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1505557"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203862"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1992.tb00801.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2017.01.002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.160929"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21972"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22773"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390105"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.104018"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000250839"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200012150-00008"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20620"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202281"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1269-1"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1996.tb01632.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/120347540200600608"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.5.601"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.161410"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.033019"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key047"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207507"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.122259"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.051706"},{"key":"e_1_2_7_27_1","first-page":"1159","article-title":"Outcome measures in psoriatic arthritis","volume":"34","author":"Gladman DD","year":"2007","journal-title":"J Rheumatol"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20967"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.100826"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(73)90035-8"}],"container-title":["Arthritis Care &amp; 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