{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T07:11:28Z","timestamp":1763968288857,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,9,27]],"date-time":"2019-09-27T00:00:00Z","timestamp":1569542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research Foundation of Flanders COFUND EU Horizon 2020","award":["FWO (Pegasus)2 EU Marie-Sklodowska Curie Fellowshi"],"award-info":[{"award-number":["FWO (Pegasus)2 EU Marie-Sklodowska Curie Fellowshi"]}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate associations between engagement in knee bending (stair climbing, kneeling, squatting, heavy lifting, getting in\/out of a squatting position) and synovitis prevalence on noncontrast magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) in individuals at risk of and with knee osteoarthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included baseline data from 594 participants (mean \u00b1 <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> age 61.5 \u00b1 8.9 years, 61% had Kellgren\/Lawrence grade \u22652; 59% were female; mean \u00b1 <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> body mass index was 30.7 \u00b1 4.8 kg\/m<jats:sup>2<\/jats:sup>) of the Osteoarthritis Biomarker Consortium Foundation for the National Institutes of Health project. Knee bending activities were queried by a standard questionnaire, and the severity of Hoffa synovitis and effusion synovitis (surrogate outcomes of synovitis) were graded using the <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> OsteoArthritis Knee Scoring system. Logistic regression was used, unadjusted and adjusted, for metabolic syndrome, physical activity level, and sex. A grade \u22651 defined synovitis prevalence, with a grade \u22652 cutoff implemented in sensitivity analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of grade \u22651 Hoffa synovitis and effusion synovitis equaled 59% (n = 353) and 62% (n = 366), respectively. Adjusted for confounders, kneeling for \u226530 minutes during a single day was associated with grade \u22651 Hoffa synovitis prevalence (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>] 1.65 [95% confidence interval (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 1.11\u20132.47]). Participants engaging in this activity \u22641 day per week had greater odds for prevalent Hoffa synovitis than those who did not perform the activity (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.88 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.11\u20133.18]). No other significant associations were found. Sensitivity analyses yielded similar findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this selected sample with a preponderance of grade \u22651 Hoffa and\/or effusion synovitis on noncontrast <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>, only prolonged kneeling was associated with Hoffa synovitis prevalence. Replication in other samples is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23760","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T05:06:20Z","timestamp":1537160780000},"page":"1372-1378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Repetitive Knee Bending and Synovitis in Individuals at Risk of and With Knee Osteoarthritis: Data From the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium"],"prefix":"10.1002","volume":"71","author":[{"given":"Ans","family":"Van Ginckel","sequence":"first","affiliation":[{"name":"Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Wittoek","sequence":"additional","affiliation":[{"name":"Ghent University Hospital and Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"De Mits","sequence":"additional","affiliation":[{"name":"Ghent University, Ghent University Hospital, and Artevelde University College  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Calders","sequence":"additional","affiliation":[{"name":"Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,27]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1645","article-title":"Occupation\u2010related squatting, kneeling, and heavy lifting and the knee joint: a magnetic resonance imaging\u2010based study in men","volume":"35","author":"Amin S","year":"2008","journal-title":"J Rheumatol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2010.01.014"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205894"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.12.006"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-010-1716-7"},{"journal-title":"Arthritis Res Care (Hoboken)","article-title":"Impact of exercise therapy on molecular biomarkers related to cartilage and inflammation in people at risk of, or with established, knee osteoarthritis: a systematic review and meta\u2010analysis of randomized controlled trials","author":"Bricca A","key":"e_1_2_6_7_1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39731"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-016-1310-6"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2011.05.004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200007)43:7<1443::AID-ANR5>3.0.CO;2-1"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-004-0561-1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4422"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2016-096489"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.150243"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.067470"}],"container-title":["Arthritis Care &amp; 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