{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:01:00Z","timestamp":1792735260505,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T00:00:00Z","timestamp":1565049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001845","name":"Scleroderma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001845","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30\u2010AR\u2010053503"],"award-info":[{"award-number":["P30\u2010AR\u2010053503"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30\u2010AR\u2010070254"],"award-info":[{"award-number":["P30\u2010AR\u2010070254"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23\u2010AR\u2010071473"],"award-info":[{"award-number":["K23\u2010AR\u2010071473"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21\u2010AR\u2010066305\u201002"],"award-info":[{"award-number":["R21\u2010AR\u2010066305\u201002"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23\u2010AR\u2010061439"],"award-info":[{"award-number":["K23\u2010AR\u2010061439"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the association of anti\u2013<jats:styled-content style=\"fixed-case\">RNPC<\/jats:styled-content>\u20103 antibodies in patients with systemic sclerosis (scleroderma or <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) with selected gastrointestinal (<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>) tract complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sera from patients with <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c with or without severe <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> dysfunction (total parenteral nutrition dependence) from the Johns Hopkins Scleroderma Center were screened for anti\u2013<jats:styled-content style=\"fixed-case\">RNPC<\/jats:styled-content>\u20103 antibodies. We then examined anti\u2013<jats:styled-content style=\"fixed-case\">RNPC<\/jats:styled-content>\u20103\u2013positive cases and negative <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c controls from the University of Pittsburgh and the University of Pittsburgh Medical Center (UPMC) scleroderma cohort to confirm our findings and to examine whether specific <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> features were associated with anti\u2013<jats:styled-content style=\"fixed-case\">RNPC<\/jats:styled-content>\u20103 antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the discovery cohort, patients with <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c with severe <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> dysfunction (n = 37) and without <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> dysfunction (n = 38) were screened for anti\u2013<jats:styled-content style=\"fixed-case\">RNPC<\/jats:styled-content>\u20103 antibodies. The former were more likely to have anti\u2013<jats:styled-content style=\"fixed-case\">RNPC<\/jats:styled-content>\u20103 antibodies (14% versus 3%; <jats:italic>P<\/jats:italic> = 0.11). In the Pittsburgh cohort, moderate\u2010to\u2010severe <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> dysfunction (Medsger <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> score \u22652) was present in 36% of anti\u2013<jats:styled-content style=\"fixed-case\">RNPC<\/jats:styled-content>\u20103\u2013positive patients versus 15% of anti\u2013<jats:styled-content style=\"fixed-case\">RNPC<\/jats:styled-content>\u20103\u2013negative patients (<jats:italic>P<\/jats:italic> \u2264 0.01). Anti\u2013<jats:styled-content style=\"fixed-case\">RNPC<\/jats:styled-content>\u20103\u2013positive patients were more likely to be male (31% versus 15%; <jats:italic>P<\/jats:italic> = 0.04), African American (18% versus 6%; <jats:italic>P<\/jats:italic> = 0.02), have esophageal dysmotility (93% versus 62%; <jats:italic>P<\/jats:italic> &lt; 0.01), and interstitial lung disease (<jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content>) (77% versus 35%; <jats:italic>P<\/jats:italic> &lt; 0.01). After adjusting for relevant covariates and potential confounders, moderate\u2010to\u2010severe <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> disease was associated with anti\u2013<jats:styled-content style=\"fixed-case\">RNPC<\/jats:styled-content>\u20103 antibodies (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>] 3.8 [95% confidence interval (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 1.0\u201314.3]), and <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content> trended toward significance (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.8 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.0\u20138.2]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c and anti\u2013<jats:styled-content style=\"fixed-case\">RNPC<\/jats:styled-content>\u20103 antibodies are more likely to be male and African American and to have moderate\u2010to\u2010severe <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> disease and <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content>. Further studies on larger patient cohorts may be helpful in further defining subsets of patients with <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c at risk for severe <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> involvement.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23763","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T09:16:44Z","timestamp":1537607804000},"page":"1164-1170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Anti\u2013<scp>RNPC<\/scp>\u20103 (U11\/U12) Antibodies in Systemic Sclerosis in Patients With Moderate\u2010to\u2010Severe Gastrointestinal Dysmotility"],"prefix":"10.1002","volume":"71","author":[{"given":"Zsuzsanna H.","family":"McMahan","sequence":"first","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn T.","family":"Domsic","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhu","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Medsger","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Casciola\u2010Rosen","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami A.","family":"Shah","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2004.08.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40065"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24586"},{"issue":"29","key":"e_1_2_7_5_1","first-page":"S42","article-title":"Assessment of disease severity and prognosis","volume":"21","author":"Medsger TA","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","unstructured":"Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. 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