{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:26:24Z","timestamp":1780471584327,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["QNT 69301"],"award-info":[{"award-number":["QNT 69301"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2019,11]]},"abstract":"Objective<\/jats:title>Identification of the incidence of juvenile idiopathic arthritis (JIA<\/jats:styled-content>)\u2013associated uveitis and its risk factors is essential to optimize early detection. Data from the Research in Arthritis in Canadian Children Emphasizing Outcomes inception cohort were used to estimate the annual incidence of new\u2010onset uveitis following JIA<\/jats:styled-content> diagnosis and to identify associated risk factors.<\/jats:p><\/jats:sec>Methods<\/jats:title>Data were reported every 6 months for 2 years, then yearly to 5 years. Incidence was determined by Kaplan\u2010Meier estimators with time of JIA<\/jats:styled-content> diagnosis as the reference point. Univariate log\u2010rank analysis identified risk factors and Cox regression determined independent predictors.<\/jats:p><\/jats:sec>Results<\/jats:title>In total, 1,183 patients who enrolled within 6 months of JIA<\/jats:styled-content> diagnosis met inclusion criteria, median age at diagnosis of 9.0 years (interquartile range [IQR<\/jats:styled-content>] 3.8\u201312.9), median follow\u2010up of 35.2 months (IQR<\/jats:styled-content> 22.7\u201348.3). Of these patients, 87 developed uveitis after enrollment. The incidence of new\u2010onset uveitis was 2.8% per year (95% confidence interval [95% CI<\/jats:styled-content>] 2.0\u20133.5) in the first 5 years. The annual incidence decreased during follow\u2010up but remained at 2.1% (95% CI<\/jats:styled-content> 0\u20134.5) in the fifth year, although confidence intervals overlapped. Uveitis was associated with young age (<7 years) at JIA<\/jats:styled-content> diagnosis (hazard ratio [HR<\/jats:styled-content>] 8.29, P<\/jats:italic> < 0.001), positive antinuclear antibody (ANA<\/jats:styled-content>) test (HR<\/jats:styled-content> 3.20, P<\/jats:italic> < 0.001), oligoarthritis (HR<\/jats:styled-content> 2.45, P<\/jats:italic> = 0.002), polyarthritis rheumatoid factor negative (HR<\/jats:styled-content> 1.65, P<\/jats:italic> = 0.002), and female sex (HR<\/jats:styled-content> 1.80, P<\/jats:italic> = 0.02). In multivariable analysis, only young age at JIA<\/jats:styled-content> diagnosis and ANA<\/jats:styled-content> positivity were independent predictors of uveitis.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Vigilant uveitis screening should continue for at least 5 years after JIA<\/jats:styled-content> diagnosis, and priority for screening should be placed on young age (<7 years) at JIA<\/jats:styled-content> diagnosis and a positive ANA<\/jats:styled-content> test.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23783","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T11:37:36Z","timestamp":1539603456000},"page":"1436-1443","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Prospective Determination of the Incidence and Risk Factors of New\u2010Onset Uveitis in Juvenile Idiopathic Arthritis: The Research in Arthritis in Canadian Children Emphasizing Outcomes Cohort"],"prefix":"10.1002","volume":"71","author":[{"given":"Jennifer J. 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