{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:27:41Z","timestamp":1785418061224,"version":"3.56.0"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T00:00:00Z","timestamp":1574985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To perform a comprehensive evaluation of and identify correlates for physical fitness in consecutive patients with juvenile idiopathic arthritis (<jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>) who have been diagnosed in the era of biologics and to compare the results with those obtained in healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study cohort included 60 patients with <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> (50 girls) ages 10\u201316 years and 60 age\u2010 and sex\u2010matched controls. The <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> group included 30 patients with persistent oligoarticular <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> and 30 patients with extended oligoarticular or polyarticular disease. Measures of physical fitness included cardiorespiratory fitness (<jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>) by peak oxygen uptake (<jats:sc>Vo<\/jats:sc><jats:sub>2peak<\/jats:sub>) during a continuous graded treadmill exercise test, muscle strength by isokinetic and isometric knee and hand grip evaluations, and bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>) and body composition by dual\u2010energy x\u2010ray absorptiometry. Physical activity was assessed by accelerometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010two percent of the patients were being treated with biologic drugs. Patients with JIA demonstrated lower muscle strength and total body <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> compared to controls, but there were no differences in <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content> and body composition. Physical fitness was comparable between the persistent oligoarticular and extended oligoarticular\/polyarticular\u2010<jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> groups. In patients with <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>, we identified associations between higher vigorous physical activity and higher <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content> and muscle strength, but did not find any association between physical fitness and disease variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this cohort of patients with <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>, we found suboptimal muscle strength and <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> compared to controls, but no differences in <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content> and body composition. Vigorous physical activities appeared important for optimizing muscle strength and <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>; the importance of such activities should be highlighted in patient education.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23818","type":"journal-article","created":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T06:16:52Z","timestamp":1543213012000},"page":"1611-1620","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Physical Fitness in Patients With Oligoarticular and Polyarticular Juvenile Idiopathic Arthritis Diagnosed in the Era of Biologics: A Controlled Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8210-0360","authenticated-orcid":false,"given":"Kristine","family":"Risum","sequence":"first","affiliation":[{"name":"Oslo University Hospital Rikshospitalet and University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Edvardsen","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Ullev\u00e5l and Norwegian School of Sports Sciences  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Godang","sequence":"additional","affiliation":[{"name":"Oslo University Hospital, Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Selvaag","sequence":"additional","affiliation":[{"name":"Oslo University Hospital, Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rge H.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Norwegian School of Sports Sciences  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8yvind","family":"Molberg","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Rikshospitalet and University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Bollerslev","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Rikshospitalet and University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger","family":"Holm","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Rikshospitalet and University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Dagfinrud","sequence":"additional","affiliation":[{"name":"Diakonhjemmet Hospital and University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helga","family":"Sanner","sequence":"additional","affiliation":[{"name":"Oslo University Hospital, Rikshospitalet and Bj\u00f8rknes University College  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60244-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20460"},{"key":"e_1_2_7_4_1","volume-title":"Pediatric Exercise Medicine: From Physiologic Principles to Health Care Application","author":"Bar\u2010Or O","year":"2004"},{"key":"e_1_2_7_5_1","first-page":"2643","article-title":"Aerobic fitness in children with juvenile idiopathic arthritis: a systematic review","volume":"29","author":"Takken T","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_7_6_1","first-page":"1834","article-title":"Cardiopulmonary exercise testing in juvenile idiopathic arthritis","volume":"31","author":"Metin G","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22897"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22893"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-010-1199-2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-10-27"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2015.1057862"},{"key":"e_1_2_7_12_1","first-page":"947","article-title":"Lower extremity isometric strength in children with juvenile idiopathic arthritis","volume":"26","author":"Saarinen J","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2003.11.017"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh381"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-11-7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2014-0378"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803774"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-015-0061-5"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206034"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-014-0196-4"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.02.003"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEP.0b013e31824cce6e"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.10.1172"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20963"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-012-1947-y"},{"key":"e_1_2_7_26_1","first-page":"619023","article-title":"Assessment of the body composition and parameters of the cardiovascular risk in juvenile idiopathic arthritis","volume":"2015","author":"Jednacz E","year":"2015","journal-title":"BioMed Res Int i"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-018-0281-6"},{"key":"e_1_2_7_28_1","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty RE","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7244.1240"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.45.239.13"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.44.235.291"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-014-0094-0"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24516"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20497"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780371209"},{"key":"e_1_2_7_36_1","first-page":"1851","article-title":"Measuring disability in early juvenile rheumatoid arthritis: evaluation of a Norwegian version of the childhood Health Assessment Questionnaire","volume":"25","author":"Flato B","year":"1998","journal-title":"J Rheumatol"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1249\/00003677-197400020-00006"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-003-1573-2"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/02640410802334196"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318206476e"},{"key":"e_1_2_7_41_1","unstructured":"KolleE StokkeJS HansenBH AnderssenS.Physical activity in 6\u2010 9\u2010 and 15\u2010year\u2010olds in Norway. Results from a survey in 2011;2012."},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2008.00709.x"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1249\/00003677-199401000-00016"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp.2017.04.01"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23683"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0b013e31819df407"},{"key":"e_1_2_7_47_1","unstructured":"World Health Organization.Global Recommendations on Physical Activity for Health 5\u201017 years old;2011. URL:https\u200b:\/\/www.who.int\/dietp\u200bhysic\u200balact\u200bivity\/\u200bfacts\u200bheet_young_peopl\u200be\/en\/."}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.23818","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.23818","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acr.23818","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.23818","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T16:13:42Z","timestamp":1759421622000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.23818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,29]]},"references-count":46,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1002\/acr.23818"],"URL":"https:\/\/doi.org\/10.1002\/acr.23818","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,29]]},"assertion":[{"value":"2018-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}