{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:57:37Z","timestamp":1792119457228,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T00:00:00Z","timestamp":1577404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Patients with immune\u2010mediated inflammatory diseases such as rheumatoid arthritis or systemic lupus erythematosus are at increased risk of cardiovascular disease. However, the cardiovascular risk of patients with primary Sj\u00f6gren's syndrome (SS) remains poorly studied. We aimed to investigate the association between primary SS and cardiovascular morbidity and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a systematic review of articles in Medline and the Cochrane Library and recent abstracts from US and European meetings, searching for reports of randomized controlled studies of cardiovascular morbidity and cardiovascular mortality in primary SS. The relative risk (RR) values for cardiovascular morbidity and mortality associated with primary SS were collected and pooled in a meta\u2010analysis with a random\u2010effects model by using Review Manager (Cochrane collaboration).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The literature search revealed 484 articles and abstracts of interest; 14 studies (67,124 patients with primary SS) were included in the meta\u2010analysis. With primary SS versus control populations, the risk was significantly increased for coronary morbidity (RR 1.34 [95% confidence interval (95% CI) 1.06\u20131.38]; <jats:italic>P<\/jats:italic> = 0.01), cerebrovascular morbidity (RR 1.46 [95% CI 1.43\u20131.49]; <jats:italic>P<\/jats:italic> &lt; 0.00001), heart failure rate (odds ratio 2.54 [95% CI 1.30\u20134.97]; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.007), and thromboembolic morbidity (RR 1.78 [95% CI 1.41\u20132.25]; <jats:italic>P<\/jats:italic> &lt; 0.00001), with no statistically significant increased risk of cardiovascular mortality (RR 1.48 [95% CI 0.77\u20132.85]; <jats:italic>P<\/jats:italic> = 0.24).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This meta\u2010analysis demonstrates that primary SS is associated with increased cardiovascular morbidity, which suggests that these patients should be screened for cardiovascular comorbidities and considered for preventive interventions, in a multidisciplinary approach with cardiologists.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23821","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T11:12:18Z","timestamp":1545304338000},"page":"131-139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Cardiovascular Morbidity and Mortality in Primary Sj\u00f6gren's Syndrome: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"72","author":[{"given":"Aur\u00e9lie","family":"Beltai","sequence":"first","affiliation":[{"name":"CHU Montpellier University of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Barnetche","sequence":"additional","affiliation":[{"name":"Bordeaux University Hospital  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Daien","sequence":"additional","affiliation":[{"name":"CHU Montpellier University of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Lukas","sequence":"additional","affiliation":[{"name":"CHU Montpellier University of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Gaujoux\u2010Viala","sequence":"additional","affiliation":[{"name":"Teaching Hospital of N\u00eemes, N\u00eemes, and University of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Combe","sequence":"additional","affiliation":[{"name":"CHU Montpellier University of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Morel","sequence":"additional","affiliation":[{"name":"CHU Montpellier University of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205375"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.122037"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.07.010"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32835fd7f8"},{"key":"e_1_2_7_6_1","unstructured":"Review Manager (RevMan) [computer program]. 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