{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:59:03Z","timestamp":1789675143620,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T00:00:00Z","timestamp":1582761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To estimate the impact of enthesitis on patient\u2010reported outcomes in children with juvenile idiopathic arthritis (<jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>), irrespective of <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> category.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children enrolled in the Research in Arthritis in Canadian Children Emphasizing Outcomes cohort were studied. Entheseal tenderness by physician examination in 33 defined locations, Juvenile Arthritis Quality of Life Questionnaire (<jats:styled-content style=\"fixed-case\">JAQQ<\/jats:styled-content>), Quality of My Life (Qo<jats:styled-content style=\"fixed-case\">ML<\/jats:styled-content>) Questionnaire, Childhood Health Assessment Questionnaire (C\u2010<jats:styled-content style=\"fixed-case\">HAQ<\/jats:styled-content>), and a pain visual analog scale were completed at enrollment, every 6 months for 2 years, and then yearly up to 5 years. Analyses consisted of descriptive statistics, linear mixed models for longitudinal data, and analysis of covariance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1,371 patients followed for a median of 35.3 months (interquartile range 22.1, 49.2), 214 (16%) had enthesitis, of whom 137 (64%) were classified as having enthesitis\u2010related arthritis. After adjusting for <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> category and covariates, children with enthesitis reported higher <jats:styled-content style=\"fixed-case\">JAQQ<\/jats:styled-content> (mean raw score 2.71 versus 2.16, adjusted difference 0.41 points; 95% confidence interval [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 0.22, 0.59), higher C\u2010<jats:styled-content style=\"fixed-case\">HAQ<\/jats:styled-content> (0.47 versus 0.31, adjusted difference 0.14 points; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.07, 0.22), higher pain (3.01 versus 1.68, adjusted difference 0.94 points; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.64, 1.25), and lower Qo<jats:styled-content style=\"fixed-case\">ML<\/jats:styled-content> (7.02 versus 8.23, adjusted difference \u20130.80 points; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u20131.09, \u20130.51) scores than children without enthesitis. These differences persisted up to 5 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Children with enthesitis, regardless of <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> category, report worse patient\u2010reported outcomes than those without enthesitis. Thus, enthesitis should be assessed in all children with <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23844","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T04:05:06Z","timestamp":1549857906000},"page":"441-446","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Worse Quality of Life, Function, and Pain in Children With Enthesitis, Irrespective of Their Juvenile Arthritis Category"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9211-4640","authenticated-orcid":false,"given":"Dax G.","family":"Rumsey","sequence":"first","affiliation":[{"name":"University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8977-2581","authenticated-orcid":false,"given":"Jaime","family":"Guzman","sequence":"additional","affiliation":[{"name":"University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan M.","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Huber","sequence":"additional","affiliation":[{"name":"Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosie","family":"Scuccimarri","sequence":"additional","affiliation":[{"name":"McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie J.","family":"Shiff","sequence":"additional","affiliation":[{"name":"University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Bruns","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Feldman","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children and University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean T.","family":"Eurich","sequence":"additional","affiliation":[{"name":"University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Research in Arthritis in Canadian Children Emphasizing Outcomes Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21840"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.150092"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120642"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-24145-8.00015-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.103"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22173"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.084244"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205372"},{"key":"e_1_2_7_10_1","first-page":"738","article-title":"The Juvenile Arthritis Quality of Life Questionnaire: development of a new responsive index for juvenile rheumatoid arthritis and juvenile spondyloarthritides","volume":"24","author":"Duffy CM","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_7_11_1","first-page":"581","article-title":"The Quality of My Life questionnaire: the minimal clinically important difference for pediatric rheumatology patients","volume":"34","author":"Gong GM","year":"2007","journal-title":"J Rheumatol"},{"key":"e_1_2_7_12_1","first-page":"150","article-title":"Minimal clinically important differences of the childhood health assessment questionnaire","volume":"32","author":"Brunner HI","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mem.2001.111517"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23236"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23256"}],"container-title":["Arthritis Care &amp; 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