{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T06:41:35Z","timestamp":1773470495910,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T00:00:00Z","timestamp":1582761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Pfizer Finland"},{"DOI":"10.13039\/501100007083","name":"Orionin Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007083","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Frequent monitoring of patients with early rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) is required for achieving good outcomes. This study was undertaken to investigate the influence of text message (<jats:styled-content style=\"fixed-case\">SMS<\/jats:styled-content>)\u2013enhanced monitoring on early <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We randomized 166 patients with early, disease\u2010modifying antirheumatic drug\u2013naive <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> to receive <jats:styled-content style=\"fixed-case\">SMS<\/jats:styled-content>\u2010enhanced follow\u2010up or routine care. All patients attended visits at 0, 3, and 6 months, and a follow\u2010up visit at 12 months. Treatment was at the physicians\u2019 discretion. The intervention included 13 <jats:styled-content style=\"fixed-case\">SMS<\/jats:styled-content>s during weeks 0\u201324 with questions concerning medication problems (yes\/no) and disease activity (patient global assessment [Pt<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>], scale 0\u201310). Patients were contacted if response <jats:styled-content style=\"fixed-case\">SMS<\/jats:styled-content>s indicated medication problems or Pt<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> exceeded predefined thresholds. Primary outcome was 6\u2010month Boolean remission (no swollen or tender joints and normal C\u2010reactive protein levels). Quality of life (QoL; measured by the Short Form 36 survey) and Disease Activity Score in 28 joints (<jats:styled-content style=\"fixed-case\">DAS<\/jats:styled-content>28) were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six and 12\u2010month follow\u2010up data were available for 162 and 157 patients, respectively. In the intervention group, 46% of the patients (38 of 82) reported medication problems and 49% (40 of 82) reported text message Pt<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>s above the alarm limit. Remission rates at 6 months (<jats:italic>P<\/jats:italic> = 0.34) were 51% in the intervention group and 42% in the control group. These rates were 57% and 43% at 12 months (<jats:italic>P<\/jats:italic> = 0.17) in the intervention and control groups, respectively. The respective mean \u00b1 <jats:styled-content style=\"fixed-case\">SD DAS<\/jats:styled-content>28 scores for the intervention and control groups were 1.92 \u00b1 1.12 and 2.22 \u00b1 1.11 at 6 months (<jats:italic>P<\/jats:italic> = 0.09); and 1.79 \u00b1 0.91 and 2.08 \u00b1 1.22 at 12 months (<jats:italic>P<\/jats:italic> = 0.28). No differences in QoL were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study did not meet the primary outcome despite a trend favoring the intervention group. This may be explained by the notably high overall remission rates.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23846","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T04:13:59Z","timestamp":1549858439000},"page":"319-325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Automated Text Message\u2013Enhanced Monitoring Versus Routine Monitoring in Early Rheumatoid Arthritis: A Randomized Trial"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5238-8439","authenticated-orcid":false,"given":"Laura","family":"Kuusalo","sequence":"first","affiliation":[{"name":"Turku University Hospital and University of Turku  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuulikki","family":"Sokka\u2010Isler","sequence":"additional","affiliation":[{"name":"Jyv\u00e4skyl\u00e4 Central Hospital  Jyv\u00e4skyl\u00e4 Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannu","family":"Kautiainen","sequence":"additional","affiliation":[{"name":"University of Eastern Finland, Kuopio, Finland, and Folkh\u00e4lsan Research Center  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4ivi","family":"Ekman","sequence":"additional","affiliation":[{"name":"Satakunta Central Hospital  Rauma Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markku J.","family":"Kauppi","sequence":"additional","affiliation":[{"name":"P\u00e4ij\u00e4t\u2010H\u00e4me Central Hospital  Lahti Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Piril\u00e4","sequence":"additional","affiliation":[{"name":"Turku University Hospital and University of Turku  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuomas","family":"Rannio","sequence":"additional","affiliation":[{"name":"Jyv\u00e4skyl\u00e4 Central Hospital  Jyv\u00e4skyl\u00e4 Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toini","family":"Uutela","sequence":"additional","affiliation":[{"name":"Lapland Central Hospital  Rovaniemi Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Yli\u2010Kerttula","sequence":"additional","affiliation":[{"name":"Satakunta Central Hospital  Rauma Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Puolakka","sequence":"additional","affiliation":[{"name":"South Karelia Central Hospital  Lappeenranta Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the SandRA Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210715"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.141371"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0801-4"},{"key":"e_1_2_8_5_1","first-page":"CD000011","article-title":"Interventions for enhancing medication adherence","author":"Nieuwlaat R","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206593"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1151-6"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207524"},{"key":"e_1_2_8_11_1","unstructured":"The Finnish Medical Society Duodecim.Current care guidelines. 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