{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:50:31Z","timestamp":1791838231720,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The present study was undertaken to assess the long\u2010term course, remission rate, and disease burden in juvenile idiopathic arthritis (\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      ) 18 years after disease onset in a population\u2010based setting from the early biologic era.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 510 consecutive cases of\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      with disease onset between 1997 and 2000 from defined geographic regions in Denmark, Norway, Sweden, and Finland were prospectively included in this 18\u2010year cohort study. At the follow\u2010up visit, patient\u2010reported demographic and clinical data were collected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 434 (85%) of the 510 eligible\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      participants. The mean \u00b1\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      age was 24.0 \u00b1 4.4 years. The median juvenile arthritis disease activity score in 71 joints (\n                      <jats:styled-content style=\"fixed-case\">JADAS<\/jats:styled-content>\n                      \u201071) was 1.5 (interquartile range [\n                      <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                      ] 0\u20135), with the enthesitis\u2010related arthritis (\n                      <jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content>\n                      ) category of\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      having the highest median score (4.5 [\n                      <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                      1.5\u20138.5],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.003). In this cohort, 46% of patients still had active disease, and 66 (15%) were treated with synthetic disease\u2010modifying antirheumatic drugs and 84 (19%) with biologics. Inactive disease indicated by a\n                      <jats:styled-content style=\"fixed-case\">JADAS<\/jats:styled-content>\n                      \u201071 score of &lt;1 was seen in 48% of participants. Clinical remission off medication (\n                      <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>\n                      ) was documented in 33% of the participants with high variability among the\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      categories.\n                      <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>\n                      was most often seen in persistent oligoarticular and systemic arthritis and least often in\n                      <jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      A substantial proportion of the\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      cohort did not achieve\n                      <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>\n                      despite new treatment options during the study period. The\n                      <jats:styled-content style=\"fixed-case\">ERA<\/jats:styled-content>\n                      category showed the worst outcomes, and in general there is still a high burden of disease in adulthood for\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.23853","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T08:49:00Z","timestamp":1550134140000},"page":"507-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":173,"title":["Long\u2010Term Outcomes in Juvenile Idiopathic Arthritis: Eighteen Years of Follow\u2010Up in the Population\u2010Based Nordic Juvenile Idiopathic Arthritis Cohort"],"prefix":"10.1002","volume":"72","author":[{"given":"Mia","family":"Glerup","sequence":"first","affiliation":[{"name":"Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Rypdal","sequence":"additional","affiliation":[{"name":"University Hospital of North Norway and UiT \u2013 The Arctic University of Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen Dalen","family":"Arnstad","sequence":"additional","affiliation":[{"name":"NTNU \u2013 Norwegian University of Science and Technology and Levanger Hospital Nord\u2010Tr\u00f8ndelag Hospital Trust  Levanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ekelund","sequence":"additional","affiliation":[{"name":"Uppsala University, Uppsala, Sweden, and Ryhov County Hospital  Jonkoping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvi","family":"Peltoniemi","sequence":"additional","affiliation":[{"name":"Hospital for Children and Adolescents University of Helsinki  Helsinki 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