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A systematic review was conducted to compile evidence for the benefits and harms associated with treatments for these conditions.\n                      <jats:styled-content style=\"fixed-case\">GRADE<\/jats:styled-content>\n                      (Grading of Recommendations Assessment, Development and Evaluation) methodology was used to rate the quality of evidence. A group consensus process was conducted among the Voting Panel to generate the final recommendations and grade their strength. A Parent and Patient Panel used a similar consensus approach to provide patient\/caregiver preferences for key questions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010nine recommendations were developed (8 strong and 31 conditional). The quality of supporting evidence was very low or low for 90% of the recommendations. Recommendations are provided for the use of nonsteroidal antiinflammatory drugs, disease\u2010modifying antirheumatic drugs, biologics, and intraarticular and oral glucocorticoids. Recommendations for the use of physical and occupational therapy are also provided. Specific recommendations for polyarthritis address general medication use, initial and subsequent treatment, and adjunctive therapies. Good disease control, with therapeutic escalation to achieve low disease activity, was recommended. The sacroiliitis and enthesitis recommendations primarily address initial therapy and adjunctive therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This guideline provides direction for clinicians, caregivers, and patients making treatment decisions. Clinicians, caregivers, and patients should use a shared decision\u2010making process that accounts for patients\u2019 values, preferences, and comorbidities. These recommendations should not be used to limit or deny access to therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.23870","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T11:40:52Z","timestamp":1556192452000},"page":"717-734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":304,"title":["2019 American College of Rheumatology\/Arthritis Foundation Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Non\u2010Systemic Polyarthritis, Sacroiliitis, and Enthesitis"],"prefix":"10.1002","volume":"71","author":[{"given":"Sarah","family":"Ringold","sequence":"first","affiliation":[{"name":"Seattle Children\u2019s Hospital  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila T.","family":"Angeles\u2010Han","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Beukelman","sequence":"additional","affiliation":[{"name":"University of Alabama  Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Lovell","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center University of Cincinnati  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Cuello","sequence":"additional","affiliation":[{"name":"McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara L.","family":"Becker","sequence":"additional","affiliation":[{"name":"Children\u2019s Mercy Hospital  Kansas City Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Colbert","sequence":"additional","affiliation":[{"name":"National Institutes of Health  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Feldman","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children and the University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polly J.","family":"Ferguson","sequence":"additional","affiliation":[{"name":"University of Iowa Carver College of Medicine  Iowa City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Gewanter","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Richmond Virginia Commonwealth University  Richmond"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Guzman","sequence":"additional","affiliation":[{"name":"BC Children\u2019s Hospital  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Horonjeff","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Nigrovic","sequence":"additional","affiliation":[{"name":"Brigham &amp; Women\u2019s Hospital and Boston Children\u2019s Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Ombrello","sequence":"additional","affiliation":[{"name":"National Institutes of Health  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray H.","family":"Passo","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina  Charleston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Stoll","sequence":"additional","affiliation":[{"name":"University of Alabama  Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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