{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:44:15Z","timestamp":1759452255868,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/K501311\/1"],"award-info":[{"award-number":["MR\/K501311\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK","doi-asserted-by":"publisher","award":["20164","20380","20542","21593"],"award-info":[{"award-number":["20164","20380","20542","21593"]}],"id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>In pediatric research, investigators rely on proxy reports of outcome, such as the proxy\u2010completed Childhood Health Assessment Questionnaire (C\u2010<jats:styled-content style=\"fixed-case\">HAQ<\/jats:styled-content>), to assess function in juvenile idiopathic arthritis (<jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>). As children mature, they may self\u2010complete the adult <jats:styled-content style=\"fixed-case\">HAQ<\/jats:styled-content> or the unvalidated adolescent\u2010specific C\u2010<jats:styled-content style=\"fixed-case\">HAQ<\/jats:styled-content>. It is unclear how these measures compare and whether they are directly interchangeable. The present study was undertaken to compare agreement between the proxy\u2010completed C\u2010HAQ, adolescent\u2010specific C\u2010HAQ, and the HAQ at initial presentation to pediatric rheumatologic care and 1 year following the first presentation in adolescents with <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adolescents ages 11\u201317 years participating in the Childhood Arthritis Prospective Study (<jats:styled-content style=\"fixed-case\">CAPS<\/jats:styled-content>), a <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> multicenter inception cohort, were included. In a <jats:styled-content style=\"fixed-case\">CAPS<\/jats:styled-content> substudy, adolescents self\u2010completed the adolescent\u2010specific C\u2010<jats:styled-content style=\"fixed-case\">HAQ<\/jats:styled-content> and the <jats:styled-content style=\"fixed-case\">HAQ<\/jats:styled-content>, and proxies simultaneously completed the proxy\u2010completed C\u2010<jats:styled-content style=\"fixed-case\">HAQ<\/jats:styled-content> at baseline and 1 year. Correlation and agreement between scores were assessed at baseline. Agreement and ability to similarly classify clinically important changes over time were assessed at 1 year following initial presentation to rheumatologic care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 107 adolescents (adolescent\u2010specific C\u2010<jats:styled-content style=\"fixed-case\">HAQ<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HAQ<\/jats:styled-content>) or their proxies (proxy\u2010completed C\u2010<jats:styled-content style=\"fixed-case\">HAQ<\/jats:styled-content>) had completed all 3 measures at baseline. Median age at diagnosis was 13 years, and 61% were female. Although the 3 scores demonstrated strong correlations (r &gt; 0.8), they were not completely interchangeable, with agreement ranging between 70% and 80%. There was similar agreement between the changes in scores between baseline and 1 year. Using proxy\u2010completed C\u2010<jats:styled-content style=\"fixed-case\">HAQ<\/jats:styled-content> minimum clinically important cutoffs, the adolescent\u2010specific C\u2010<jats:styled-content style=\"fixed-case\">HAQ<\/jats:styled-content> and the <jats:styled-content style=\"fixed-case\">HAQ<\/jats:styled-content> similarly classified 80% to 90% of adolescents as having improved or worsened.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While there is relatively high agreement and similar classification of change between <jats:styled-content style=\"fixed-case\">HAQ<\/jats:styled-content> and the 2 C\u2010<jats:styled-content style=\"fixed-case\">HAQ<\/jats:styled-content> scores, these are not completely interchangeable. This impacts the comparison of function when measured in different ways over the lifespan.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23877","type":"journal-article","created":{"date-parts":[[2019,3,16]],"date-time":"2019-03-16T02:00:07Z","timestamp":1552701607000},"page":"517-524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparing Proxy, Adolescent, and Adult Assessments of Functional Ability in Adolescents With Juvenile Idiopathic Arthritis"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9441-5535","authenticated-orcid":false,"given":"Stephanie J. W.","family":"Shoop\u2010Worrall","sequence":"first","affiliation":[{"name":"University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimme L.","family":"Hyrich","sequence":"additional","affiliation":[{"name":"University of Manchester and Central Manchester University Hospitals NHS Foundation Trust Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne M. M.","family":"Verstappen","sequence":"additional","affiliation":[{"name":"University of Manchester and Central Manchester University Hospitals NHS Foundation Trust Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9000-4413","authenticated-orcid":false,"given":"Jamie C.","family":"Sergeant","sequence":"additional","affiliation":[{"name":"University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"Baildam","sequence":"additional","affiliation":[{"name":"Alder Hey Children\u2019s NHS Foundation Trust  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Chieng","sequence":"additional","affiliation":[{"name":"Royal Manchester Children\u2019s Hospital  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce","family":"Davidson","sequence":"additional","affiliation":[{"name":"Royal Hospital for Children, Glasgow, UK and Royal Hospital for Sick Children  Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Foster","sequence":"additional","affiliation":[{"name":"Great North Children\u2019s Hospital Newcastle Hospitals NHS Foundation Trust and Newcastle University  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiannis","family":"Ioannou","sequence":"additional","affiliation":[{"name":"University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flora","family":"McErlane","sequence":"additional","affiliation":[{"name":"Great North Children\u2019s Hospital Newcastle Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy R.","family":"Wedderburn","sequence":"additional","affiliation":[{"name":"University College London Great Ormond Street Hospital NHS Foundation Trust and NIHR Great Ormond Street Hospital Biomedical Research Centre  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Thomson","sequence":"additional","affiliation":[{"name":"Central Manchester University Hospitals NHS Foundation Trust Manchester Academic Health Science Centre and University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet E.","family":"McDonagh","sequence":"additional","affiliation":[{"name":"Central Manchester University Hospitals NHS Foundation Trust Manchester Academic Health Science Centre and University of Manchester  Manchester 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