{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:09:31Z","timestamp":1783721371025,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24 AR 057827"],"award-info":[{"award-number":["K24 AR 057827"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AR 072577"],"award-info":[{"award-number":["P30 AR 072577"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","award":["Investigator Award"],"award-info":[{"award-number":["Investigator Award"]}],"id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR05557"],"award-info":[{"award-number":["R01AR05557"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The present study was undertaken to evaluate changes in knee magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) findings over the course of 18 months in subjects with osteoarthritic change and meniscal tear treated with arthroscopic partial meniscectomy (<jats:styled-content style=\"fixed-case\">APM<\/jats:styled-content>) or nonoperatively with physical therapy (<jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used 18\u2010month follow\u2010up data from the Meniscal Tear in Osteoarthritis Research Trial. <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> results were read with reference to the <jats:styled-content style=\"fixed-case\">MRI Osteoarthritis<\/jats:styled-content> Knee Score. We focused on 18\u2010month change in bone marrow lesions (<jats:styled-content style=\"fixed-case\">BML<\/jats:styled-content>s), cartilage thickness, cartilage surface area, osteophyte size, effusion\u2010synovitis, and Hoffa\u2010synovitis. We used multinomial logistic regression to assess associations between <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\u2010based changes in each feature and treatment type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 351 subjects were randomized, and 225 had both baseline and 18\u2010month <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> results. In both treatment groups, patients experienced substantial changes in several <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\u2010based markers. In 60% of the <jats:styled-content style=\"fixed-case\">APM<\/jats:styled-content> group, versus 33% of the <jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content> group, cartilage surface area damage advanced in \u22652 subregions (adjusted odds ratio 4.2 [95% confidence interval 2.0\u20139.0). Patients who underwent <jats:styled-content style=\"fixed-case\">APM<\/jats:styled-content> also had greater advancement in scores for osteophytes and effusion\u2010synovitis. We did not find significant associations between treatment type and change in cartilage thickness, <jats:styled-content style=\"fixed-case\">BML<\/jats:styled-content>s, or Hoffa\u2010synovitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This cohort of patients with meniscal tear and osteoarthritis showed marked advancement in <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\u2010based features over 18 months. Patients treated with <jats:styled-content style=\"fixed-case\">APM<\/jats:styled-content> showed more advancement in some features compared to those treated nonoperatively. The clinical relevance of these early findings is unknown and requires further study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23891","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T08:40:25Z","timestamp":1554108025000},"page":"630-640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Early Magnetic Resonance Imaging\u2013Based Changes in Patients With Meniscal Tear and Osteoarthritis: Eighteen\u2010Month Data From a Randomized Controlled Trial of Arthroscopic Partial Meniscectomy Versus Physical Therapy"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8413-007X","authenticated-orcid":false,"given":"Jamie E.","family":"Collins","sequence":"first","affiliation":[{"name":"Brigham and Women\u2019s Hospital and Harvard Medical School  Boston 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