{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T07:24:23Z","timestamp":1774423463179,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","award":["Scientist Development Award"],"award-info":[{"award-number":["Scientist Development Award"]}],"id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The present study was undertaken to identify depression subtypes in individuals with or at risk for symptomatic knee osteoarthritis (OA) and to evaluate differences in pain and disability trajectories between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants (n = 4,486) were enrolled in the Osteoarthritis Initiative. Latent class analysis was applied to the 20\u2010item Center for Epidemiologic Studies Depression Scale measured at baseline to identify groups with similar patterns of depressive symptoms, and subtypes were assigned using posterior probability estimates. The relationships between depression subtypes and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and disability subscales were modeled over 4 years and stratified by baseline knee OA status (symptomatic [n = 1,626] or at risk [n = 2,860]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four subtypes were identified: asymptomatic (80.6%), catatonic (5.3%), anhedonic (10.6%), and melancholic (3.5%). Catatonic and anhedonic subtypes were differentiated by symptoms corresponding to psychomotor agitation and the inability to experience pleasure, respectively. The melancholic subtype expressed symptoms related to reduced energy and movement, anhedonia, and other somatic symptoms. Detectable mean differences in pain and disability compared to the asymptomatic group were observed for the anhedonic (1.5\u20132.3 WOMAC units) and melancholic (4.8\u20136.6 WOMAC units) subtypes, and associations were generally larger in individuals with symptomatic knee OA relative to those at risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among individuals with or at risk for symptomatic knee OA, there is evidence of depression subtypes characterized by distinct clusters of depressive symptoms that have differential effects on reports of pain and disability over time. Our findings thus imply that depression interventions could be optimized by targeting the specific symptomology that these subtypes exhibit.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23898","type":"journal-article","created":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T06:00:12Z","timestamp":1554530412000},"page":"669-678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Depression Subtypes in Individuals With or at Risk for Symptomatic Knee Osteoarthritis"],"prefix":"10.1002","volume":"72","author":[{"given":"Alan M.","family":"Rathbun","sequence":"first","affiliation":[{"name":"VA Maryland Health Care System and University of Maryland School of Medicine  Baltimore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan S.","family":"Schuler","sequence":"additional","affiliation":[{"name":"RAND Corporation  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Stuart","sequence":"additional","affiliation":[{"name":"Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle D.","family":"Shardell","sequence":"additional","affiliation":[{"name":"National Institute on Aging  Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle S.","family":"Yau","sequence":"additional","affiliation":[{"name":"Institute for Aging Research Hebrew SeniorLife  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph J.","family":"Gallo","sequence":"additional","affiliation":[{"name":"Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice S.","family":"Ryan","sequence":"additional","affiliation":[{"name":"VA Maryland Health Care System and University of Maryland School of Medicine  Baltimore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc C.","family":"Hochberg","sequence":"additional","affiliation":[{"name":"VA Maryland Health Care System and University of Maryland School of Medicine  Baltimore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23176"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2010.03.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.09.013"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2759-z"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22515"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23239"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3495-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15259"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-007-0309-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2008.09.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2011-000809"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2051-5545.2011.tb00061.x"},{"key":"e_1_2_7_14_1","first-page":"523","article-title":"A description of patient\u2010 and rheumatologist\u2010reported depression symptoms in an American rheumatoid arthritis registry population","volume":"32","author":"Rathbun AM","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.23.3095"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.151"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afw001"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.161"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2017.1307737"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-016-1319-z"},{"key":"e_1_2_7_21_1","unstructured":"NevittMC FelsonDT LesterG.The Osteoarthritis Initiative: a knee health study.2006. 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