{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T14:48:57Z","timestamp":1772722137020,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,31]],"date-time":"2020-05-31T00:00:00Z","timestamp":1590883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To estimate the cumulative incidence of arthritis\u2010induced orofacial symptoms, dysfunction, and dentofacial deformities in growing individuals with juvenile idiopathic arthritis (\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      ) in a 36\u2010month regional cohort study and to identify predictors for the development of arthritis\u2010induced dentofacial deformities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data were retrieved from the Aarhus\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      temporomandibular joint (\n                      <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>\n                      ) cohort register, which contains standardized, longitudinal, observational data regarding orofacial conditions in patients with\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      (n = 1,040). This regional cohort represents the majority of all subjects with\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      from the western part of Denmark between 1990 and 2016, regardless of\n                      <jats:styled-content style=\"fixed-case\">TMJ<\/jats:styled-content>\n                      arthritis status. Cumulative incidences of orofacial conditions were reported using Kaplan\u2010Meier methods, and predictors for dentofacial deformity were identified using Cox proportional hazards analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Follow\u2010up data from 351 subjects for 36 months were included in this study. Median age at first clinical examination was 6.6 years (interquartile range 4.8\u20139.9 years). Orofacial symptoms and dysfunctions were common findings at 36 months after the first clinical examination and 5 years after\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      onset, with a cumulative incidence of 38% and 53%, respectively. Dentofacial deformities were found in 35% of subjects at the 36\u2010month follow\u2010up and were significantly associated with the presence of orofacial dysfunction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Orofacial conditions were frequently observed in individuals with\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      and were represented in all\n                      <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>\n                      subcategories in this regional study. One\u2010third of subjects had arthritis\u2010induced dentofacial deformities that required orthopedic appliance treatment at the 36\u2010month follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/acr.23899","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T23:26:48Z","timestamp":1555025208000},"page":"907-916","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Cumulative Incidence of Orofacial Manifestations in Early Juvenile Idiopathic Arthritis: A Regional, Three\u2010Year Cohort Study"],"prefix":"10.1002","volume":"72","author":[{"given":"Peter","family":"Stoustrup","sequence":"first","affiliation":[{"name":"Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia","family":"Glerup","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders E.","family":"Bilgrau","sequence":"additional","affiliation":[{"name":"Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelise","family":"K\u00fcseler","sequence":"additional","affiliation":[{"name":"Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlalberta","family":"Verna","sequence":"additional","affiliation":[{"name":"University of Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne E.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasper D.","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven Erik","family":"N\u00f8rholt","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital and Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marinka","family":"Twilt","sequence":"additional","affiliation":[{"name":"University of Calgary and Alberta Children\u2019s Hospital  Calgary Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troels","family":"Herlin","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas K.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital and Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100325"},{"key":"e_1_2_7_3_1","first-page":"162","article-title":"A 2 year followup study of enhanced magnetic resonance imaging and clinical examination of the temporomandibular joint in children with juvenile idiopathic arthritis","volume":"32","author":"K\u00fcseler A","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.111441"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23401"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-018-0259-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23532"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009741003685624"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2017.08.022"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2017.05.037"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350902740506"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2014.06.018"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00056-012-0091-2"},{"key":"e_1_2_7_15_1","first-page":"57","volume-title":"Growth of the mandible. 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