{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:20:49Z","timestamp":1787052049660,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL071194, R01 HL070848, R01 HL070847, R01 HL07"],"award-info":[{"award-number":["R01 HL071194, R01 HL070848, R01 HL070847, R01 HL07"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["U01 AR066160"],"award-info":[{"award-number":["U01 AR066160"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG027810, U01 AG042124, U01 AG042139, U01 AG04"],"award-info":[{"award-number":["U01 AG027810, U01 AG042124, U01 AG042139, U01 AG04"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care & Research"],"published-print":{"date-parts":[[2020,7]]},"abstract":"Objective<\/jats:title>To examine the associations of prevalent arthritis with systemic inflammation in older men and to test whether sleep health mediates the associations.<\/jats:p><\/jats:sec>Methods<\/jats:title>Cross\u2010sectional data came from 2,562 community\u2010dwelling older men (all were age 65 years or older; mean age 76 years) in the Osteoporotic Fractures in Men Study who participated in a sleep ancillary study in 2003\u20132005. Participants were classified as having osteoarthritis (OA<\/jats:styled-content>) (24%) or rheumatoid arthritis (RA<\/jats:styled-content>) (0.7%) based on self\u2010reported diagnoses and medication use. We constructed a composite score of multidimensional sleep health (i.e., perceived sleep quality, sleepiness, frequency of daytime napping, wake after sleep onset, and sleep duration) measured by both self\u2010report and actigraphy. We also created binary indicators of elevated inflammation using C\u2010reactive protein (CRP<\/jats:styled-content>) (>3 mg\/liter) and interleukin\u20106 (IL<\/jats:styled-content>\u20106) (>1.08 pg\/ml) levels. Analyses controlled for age, diagnosed sleep disorders, body mass index, smoking status, relevant medication use, and comorbidities.<\/jats:p><\/jats:sec>Results<\/jats:title>Older men with OA<\/jats:styled-content> did not have higher risk of elevated CRP<\/jats:styled-content> or IL<\/jats:styled-content>\u20106 levels. However, indirect associations of OA<\/jats:styled-content> through sleep health were found. OA<\/jats:styled-content> was associated with poorer sleep health, which was further associated with 16% higher odds of elevated CRP<\/jats:styled-content> (P<\/jats:italic> < 0.001) and 12% higher odds of elevated IL<\/jats:styled-content>\u20106 (P<\/jats:italic> < 0.01) levels after controlling for OA<\/jats:styled-content>. Older men with RA<\/jats:styled-content> had higher odds of elevated CRP<\/jats:styled-content> and IL<\/jats:styled-content>\u20106 levels, but the associations were not mediated by sleep health.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Findings suggest that promoting sleep health may help reduce the risk of systemic inflammation in older men with OA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23923","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T05:35:12Z","timestamp":1557466512000},"page":"965-973","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Arthritis, Sleep Health, and Systemic Inflammation in Older Men"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7623-3770","authenticated-orcid":false,"given":"Soomi","family":"Lee","sequence":"first","affiliation":[{"name":"University of South Florida, Tampa, and 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