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Estimates of n\u20103 and n\u20106 intake were derived from Diet History Questionnaire II items (past year with portion size version). Patient\u2010reported outcomes included self\u2010reported lupus activity (Systemic Lupus Activity Questionnaire [SLAQ]). Multivariable regression, adjusted for age, sex, race, and body mass index, was used to assess associations between absolute intake of n\u20103 and n\u20106, as well as the n\u20106:n\u20103 ratio, and patient\u2010reported outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 456 SLE cases, 425 (93.2%) were female, 207 (45.4%) were African American, and the mean \u00b1 SD age was 52.9 \u00b1 12.3 years. Controlling for potential confounders, the average SLAQ score was significantly higher by 0.3 points (95% confidence interval [95% CI] 0.1, 0.6; <jats:italic>P<\/jats:italic> = 0.013) with each unit increase of the n\u20106:n\u20103 ratio. Both lupus activity and Patient\u2010Reported Outcomes Measurement Information System (PROMIS) sleep disturbance scores were lower with each 1\u2010gram\/1,000 kcal increase of n\u20103 fatty acids (SLAQ regression coefficient \u03b2 = \u20130.8 [95% CI \u20131.6, 0.0]; <jats:italic>P<\/jats:italic> = 0.055; PROMIS sleep \u03b2 = \u20131.1 [95% CI \u20132.0, \u20130.2]; <jats:italic>P<\/jats:italic> = 0.017). Higher n\u20103 intakes were nonsignificantly associated with lower levels of depressive symptoms and comorbid fibromyalgia, and with higher quality of life, whereas results for the n6:n3 ratio trended in the opposite direction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This population\u2010based study suggests that higher dietary intake of n\u20103 fatty acids and lower n\u20106:n\u20103 ratios are favorably associated with patient\u2010reported outcomes in SLE, particularly self\u2010reported lupus activity and sleep quality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23925","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T07:35:46Z","timestamp":1557473746000},"page":"874-881","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Dietary Omega Polyunsaturated Fatty Acid Intake and Patient\u2010Reported Outcomes in Systemic Lupus Erythematosus: The Michigan Lupus Epidemiology and Surveillance Program"],"prefix":"10.1002","volume":"72","author":[{"given":"Prae","family":"Charoenwoodhipong","sequence":"first","affiliation":[{"name":"University of Michigan Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sioban D.","family":"Harlow","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7963-4206","authenticated-orcid":false,"given":"Wendy","family":"Marder","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afton L.","family":"Hassett","sequence":"additional","affiliation":[{"name":"University of Michigan Ann Arbor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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