{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:30:38Z","timestamp":1793035838468,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T00:00:00Z","timestamp":1591488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["U54GM115458"],"award-info":[{"award-number":["U54GM115458"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008291","name":"College of Medicine, University of Nebraska Medical Center","doi-asserted-by":"publisher","award":["No grant number assigned"],"award-info":[{"award-number":["No grant number assigned"]}],"id":[{"id":"10.13039\/100008291","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care & Research"],"published-print":{"date-parts":[[2020,7]]},"abstract":"\n Objective<\/jats:title>\n \n Although hyperuricemia and gout can complicate the course of rheumatoid arthritis (\n RA<\/jats:styled-content>\n ), the impact of these factors on outcomes in\n RA<\/jats:styled-content>\n is unclear. We undertook this study to examine associations of coexistent hyperuricemia and gout with\n RA<\/jats:styled-content>\n disease measures,\n RA<\/jats:styled-content>\n treatments, and survival.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Participants from a longitudinal\n RA<\/jats:styled-content>\n study were categorized by the presence of gout and serum urate (\n UA<\/jats:styled-content>\n ) status. Groups were compared by baseline patient characteristics,\n RA<\/jats:styled-content>\n disease activity, treatments, and comorbidities. Associations of baseline serum\n UA<\/jats:styled-content>\n levels with all\u2010cause and cardiovascular disease (\n CVD<\/jats:styled-content>\n )\u2013related mortality were examined in multivariable survival analyses.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 1,999 participants with\n RA<\/jats:styled-content>\n , 341 (17%) had serum\n UA<\/jats:styled-content>\n concentrations of >6.8 mg\/dl, and 121 (6.1%) were diagnosed with gout. There were no significant associations of serum\n UA<\/jats:styled-content>\n concentration or gout with\n RA<\/jats:styled-content>\n disease activity or treatment at enrollment, with the exception that those with gout were more likely to be receiving sulfasalazine and less likely to be receiving nonsteroidal antiinflammatory drugs. After adjustments for age and sex, moderate hyperuricemia (serum\n UA<\/jats:styled-content>\n >6.8 to \u22648 mg\/dl) was associated with an increased risk of\n CVD<\/jats:styled-content>\n \u2010related mortality (hazard ratio 1.56 [95% confidence interval 1.11\u20132.21]). This association was attenuated and not significant following additional adjustment for comorbidities that more commonly accompany hyperuricemia. Results corresponding with serum\n UA<\/jats:styled-content>\n concentrations of >8.0 mg\/dl were similar, although not reaching statistical significance in any model. There were no associations of baseline serum\n UA<\/jats:styled-content>\n concentration with all\u2010cause mortality.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Our study reports the frequency of hyperuricemia and gout in patients with\n RA<\/jats:styled-content>\n . These results demonstrate strong associations of hyperuricemia with\n CVD<\/jats:styled-content>\n mortality in this population, a risk that appears to be driven by excess comorbidity.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/acr.23926","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T07:35:53Z","timestamp":1557473753000},"page":"950-958","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Coexistent Hyperuricemia and Gout in Rheumatoid Arthritis: Associations With Comorbidities, Disease Activity, and Mortality"],"prefix":"10.1002","volume":"72","author":[{"given":"Andrew","family":"Chiou","sequence":"first","affiliation":[{"name":"University of Nebraska Medical Center Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9649-3588","authenticated-orcid":false,"given":"Bryant R.","family":"England","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center and VA Nebraska\u2013Western Iowa Health Care System Omaha Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harlan","family":"Sayles","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center Omaha"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey M.","family":"Thiele","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center and VA Nebraska\u2013Western Iowa Health Care System Omaha Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Duryee","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center and VA Nebraska\u2013Western Iowa Health Care System Omaha Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua F.","family":"Baker","sequence":"additional","affiliation":[{"name":"Corporal Michael J. Crescenz VAMC and University of Pennsylvania Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7149-363X","authenticated-orcid":false,"given":"Namrata","family":"Singh","sequence":"additional","affiliation":[{"name":"Iowa City VAMC and University of Iowa Iowa City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6640-9173","authenticated-orcid":false,"given":"Grant W.","family":"Cannon","sequence":"additional","affiliation":[{"name":"Salt Lake City VAMC and University of Utah Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail S.","family":"Kerr","sequence":"additional","affiliation":[{"name":"Washington, DC VAMC, Georgetown University, and Howard University Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Reimold","sequence":"additional","affiliation":[{"name":"Dallas VAMC and University of Texas 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