{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:53:51Z","timestamp":1774266831208,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,7,5]],"date-time":"2020-07-05T00:00:00Z","timestamp":1593907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the prevalence and clinical characteristics of juvenile idiopathic arthritis (<jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>) in Alaska Native children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Potential cases of <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> were identified by querying administrative data from hospitals and clinics in the Alaska Tribal Health System for codes possibly identifying <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>. Medical record abstraction was performed to confirm criteria met for <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>, demographic and clinical characteristics, and treatment patterns. Individuals age \u226418 years with a confirmed diagnosis of <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> were included. The denominator for prevalence was the 2015 Alaska Area Indian Health Service user population age of \u226418 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The unadjusted prevalence of <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> in Alaska Native children was 74.6 per 100,000 (age\u2010adjusted 79.0 per 100,000). <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> was more common in females than males (unadjusted prevalence 105.8 versus 45.0 per 100,000). Oligoarthritis was the most common subtype (31% of cases), but polyarthritis and enthesitis\u2010related arthritis were also common (26% and 24% of cases, respectively), with a notably high prevalence of enthesitis\u2010related arthritis. The median age at diagnosis was 9 years. Of the combined cohort with results available, 56% were antinuclear antibody positive, 23% were rheumatoid factor positive, 19% were anti\u2013cyclic citrullinated peptide antibody positive, and 57% had the presence of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2013B27. Uveitis had been diagnosed in 16% of cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> in Alaska Native children may be higher than the general <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> population. Enthesitis\u2010related arthritis makes up a higher proportion of cases than in other populations described likely because of the high prevalence of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2013B27 in this population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.23997","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T11:39:46Z","timestamp":1559302786000},"page":"1152-1158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence of Juvenile Idiopathic Arthritis in the Alaska Native Population"],"prefix":"10.1002","volume":"72","author":[{"given":"Beverly","family":"Khodra","sequence":"first","affiliation":[{"name":"University of Washington  Seattle"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"M. Stevens","sequence":"additional","affiliation":[{"name":"Seattle Children's Research Institute  Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0478-8205","authenticated-orcid":false,"given":"Elizabeth D.","family":"Ferucci","sequence":"additional","affiliation":[{"name":"Alaska Native Tribal Health Consortium  Anchorage"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60244-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206034"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-016-0088-2"},{"key":"e_1_2_7_5_1","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","author":"Petty RE","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_7_6_1","first-page":"195","article-title":"Current proposed revision of JRA criteria: JRA Criteria Subcommittee of the Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Section of the Arthritis Foundation","volume":"20","author":"Brewer EJ","year":"1977","journal-title":"Arthritis Rheum"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2013.09.003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39323"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.10.010"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2004.08.003"},{"key":"e_1_2_7_11_1","first-page":"1145","article-title":"Arthritis in aboriginal Manitobans: evidence for a high burden of disease","volume":"35","author":"Barnabe C","year":"2008","journal-title":"J Rheumatol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38720"},{"key":"e_1_2_7_13_1","first-page":"1884","article-title":"Systemic lupus erythematosus in North American Indians: a population based study","volume":"27","author":"Peschken CA","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_7_14_1","first-page":"2292","article-title":"Prevalence of spondyloarthropathies in Alaskan Eskimos","volume":"21","author":"Boyer GS","year":"1994","journal-title":"J Rheumatol"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-5-30"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290109"},{"key":"e_1_2_7_17_1","first-page":"1477","article-title":"Rheumatic diseases in Alaskan Indians of the southeast coast: high prevalence of rheumatoid arthritis and systemic lupus erythematosus","volume":"18","author":"Boyer GS","year":"1991","journal-title":"J Rheumatol"},{"key":"e_1_2_7_18_1","first-page":"1","article-title":"Age adjustment using the 2000 projected U.S. population. 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