{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:07:27Z","timestamp":1792030047236,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK","doi-asserted-by":"publisher","award":["20164"],"award-info":[{"award-number":["20164"]}],"id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore whether anxiety and depression are associated with clinical measures of disease for adolescent patients with juvenile idiopathic arthritis (<jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>) and whether anxiety and depression are associated with increased peripheral proinflammatory cytokine levels in adolescent patients with <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> and in healthy adolescent controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 136 patients with <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> and 88 healthy controls ages 13\u201318 years completed questionnaires on anxiety and depressive symptoms. For patients with <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>, pain, disability, physician global assessment (using a visual analog scale [<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>]), and number of joints with active inflammation (active joint count) were recorded. In a subsample, we assessed lipopolysaccharide\u2010stimulated interleukin 6 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106) production from peripheral blood mononuclear cells, serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, cortisol, and C\u2010reactive protein levels. Data were analyzed by linear regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Levels of anxiety and depressive symptoms in patients with <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> were not significantly different than those in healthy controls. For patients with <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>, anxiety was significantly associated with disability (\u03b2 = 0.009, <jats:italic>P<\/jats:italic> = 0.002), pain (\u03b2 = 0.029, <jats:italic>P<\/jats:italic> = 0.011), and physician global assessment <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> (\u03b2 = 0.019, <jats:italic>P<\/jats:italic> = 0.012), but not with active joint count (\u03b2 = 0.014, <jats:italic>P<\/jats:italic> = 0.120). Anxiety was not associated with any laboratory measures of inflammation for <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> patients. These relationships were also true for depressive symptoms. For healthy controls, there was a trend toward an association of anxiety (but not depressive symptoms) with stimulated <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 (\u03b2 = 0.004, <jats:italic>P<\/jats:italic> = 0.052).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adolescent patients with <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> experience equivalent levels of anxiety and depressive symptoms as healthy adolescents. For adolescent patients with <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>, anxiety and depressive symptoms are associated with pain, disability, and physician global assessment <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>, but not with inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24006","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T11:09:16Z","timestamp":1560510556000},"page":"1266-1274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Association of Anxiety With Pain and Disability but Not With Increased Measures of Inflammation in Adolescent Patients With Juvenile Idiopathic Arthritis"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2323-8391","authenticated-orcid":false,"given":"Laura","family":"Hanns","sequence":"first","affiliation":[{"name":"University College London  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