{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:45:29Z","timestamp":1791805529392,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T00:00:00Z","timestamp":1591488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care & Research"],"published-print":{"date-parts":[[2020,7]]},"abstract":"\n Objective<\/jats:title>\n \n Osteoarthritis (\n OA<\/jats:styled-content>\n ) is a common chronic condition in older individuals, but its association with other chronic conditions is largely unknown. This study aimed to systematically review the literature on comorbidities in individuals with\n OA<\/jats:styled-content>\n compared to those without.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We searched 4 databases for observational studies on comorbidities in individuals with\n OA<\/jats:styled-content>\n . Studies of\n OA<\/jats:styled-content>\n only or in comparison with non\u2010\n OA<\/jats:styled-content>\n controls were included. The risk of bias and study quality were assessed using the Newcastle\u2010Ottawa Scale. The prevalence of comorbidities in the\n OA<\/jats:styled-content>\n group and the prevalence ratio (\n PR<\/jats:styled-content>\n ) and 95% confidence interval (95%\n CI<\/jats:styled-content>\n ) between\n OA<\/jats:styled-content>\n and non\u2010\n OA<\/jats:styled-content>\n groups were calculated.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In all, 42 studies from 16 countries (27 case\u2010only and 15 comparative studies) met the inclusion criteria. The mean age of participants varied from 51 to 76 years. The pooled prevalence of any comorbidity was 67% (95%\n CI<\/jats:styled-content>\n 57\u201374) in individuals with\n OA<\/jats:styled-content>\n versus 56% (95%\n CI<\/jats:styled-content>\n 44\u201368) in individuals without\n OA<\/jats:styled-content>\n . The pooled\n PR<\/jats:styled-content>\n for any comorbidity was 1.21 (95%\n CI<\/jats:styled-content>\n 1.02\u20131.45). The\n PR<\/jats:styled-content>\n increased from 0.73 (95%\n CI<\/jats:styled-content>\n 0.43\u20131.25) for 1 comorbidity to 1.58 (95%\n CI<\/jats:styled-content>\n 1.03\u20132.42) for 2, and to 1.94 (95%\n CI<\/jats:styled-content>\n 1.45\u20132.59) for \u22653 comorbidities. The key comorbidities associated with\n OA<\/jats:styled-content>\n were stroke (\n PR<\/jats:styled-content>\n 2.61 [95%\n CI<\/jats:styled-content>\n 2.13\u20133.21]), peptic ulcer (\n PR<\/jats:styled-content>\n 2.36 [95%\n CI<\/jats:styled-content>\n 1.71\u20133.27]), and metabolic syndrome (\n PR<\/jats:styled-content>\n 1.94 [95%\n CI<\/jats:styled-content>\n 1.21\u20133.12]).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Individuals with\n OA<\/jats:styled-content>\n are more likely to have other chronic conditions. The association is dose\u2010dependent in terms of the number of comorbidities, suggesting multimorbidities. Further studies on the causality of this association and clinical implications are needed.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/acr.24008","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T14:50:03Z","timestamp":1560783003000},"page":"991-1000","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":272,"title":["Comorbidities in Osteoarthritis: A Systematic Review and Meta\u2010Analysis of Observational Studies"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9207-1065","authenticated-orcid":false,"given":"Subhashisa","family":"Swain","sequence":"first","affiliation":[{"name":"University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8390-6876","authenticated-orcid":false,"given":"Aliya","family":"Sarmanova","sequence":"additional","affiliation":[{"name":"University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Coupland","sequence":"additional","affiliation":[{"name":"School of Medicine University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Doherty","sequence":"additional","affiliation":[{"name":"University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiya","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638280902736809"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/lds038"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-015-0355-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-2-51"},{"key":"e_1_2_7_6_1","first-page":"168","article-title":"Co\u2010morbidities of patients with knee osteoarthritis","volume":"15","author":"Chan KW","year":"2009","journal-title":"Hong Kong Med J"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.007526"},{"key":"e_1_2_7_8_1","unstructured":"Centers for Disease Control and Prevention.Comorbidities: what does \u201ccomorbidity\u201d mean?2018. 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