{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T05:50:17Z","timestamp":1793512217380,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T00:00:00Z","timestamp":1593734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2020,8]]},"abstract":"Objective<\/jats:title>To determine if low disease activity state (LDAS<\/jats:styled-content>)\/remission predicts a better health\u2010related quality of life (HRQ<\/jats:styled-content>oL).<\/jats:p><\/jats:sec>Methods<\/jats:title>Patients with systemic lupus erythematosus from a single center and having completed at least 2 visits were included. Visits were performed every 6 months. HRQ<\/jats:styled-content>oL was measured with the LupusQoL questionnaire. The definition of remission included a Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI<\/jats:styled-content>\u20102K) score of 0, prednisone daily dosage of \u22645 mg\/day, and immunosuppressive drugs on maintenance dose. LDAS<\/jats:styled-content> was defined as a SLEDAI<\/jats:styled-content>\u20102K score of \u22644, prednisone daily dosage of \u22647.5 mg\/day, and immunosuppressive drugs as maintenance therapy. For these analyses, remission and LDAS<\/jats:styled-content> were combined as one variable. Generalized estimating equations were calculated, using as the outcome 1 of each of the 8 components of the LupusQoL questionnaire in the subsequent visit and the activity state in the previous visit. Multivariable models were adjusted for possible confounders.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 243 patients were included. During the follow\u2010up, 590 visits (61.6%) were categorized as LDAS<\/jats:styled-content>\/remission. LDAS<\/jats:styled-content>\/remission predicted a better HRQ<\/jats:styled-content>oL in the components of physical health (B = 4.17 [95% confidence interval (95% CI<\/jats:styled-content>) 1.20, 7.14]; P<\/jats:italic> = 0.006), pain (B = 6.47 [95% CI<\/jats:styled-content> 3.18, 9.76]; P<\/jats:italic> < 0.001), planning (B = 4.97 [95% CI<\/jats:styled-content> 1.43, 8.52]; P<\/jats:italic> = 0.006), burden to others (B = 4.12 [95% CI<\/jats:styled-content> 0.24, 8.01]; P<\/jats:italic> = 0.037], emotional health (B = 4.50 [95% CI<\/jats:styled-content> 1.56, 7.44]; P<\/jats:italic> = 0.003), and fatigue (B = 3.25 [95% CI<\/jats:styled-content> 0.04, 6.47]; P<\/jats:italic> = 0.048).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Being in LDAS<\/jats:styled-content>\/remission predicts a better HRQ<\/jats:styled-content>oL, especially in the components of physical health, pain, planning, burden to others, emotional health, and fatigue.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24009","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T11:08:55Z","timestamp":1560510535000},"page":"1159-1162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Better Health\u2010Related Quality of Life in Systemic Lupus Erythematosus Predicted by Low Disease Activity State\/Remission: Data From the Peruvian Almenara Lupus Cohort"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1728-1999","authenticated-orcid":false,"given":"Manuel F.","family":"Ugarte\u2010Gil","sequence":"first","affiliation":[{"name":"Hospital Guillermo Almenara Irigoyen EsSalud and School of Medicine Universidad Cient\u00edfica del Sur Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo V.","family":"Gamboa\u2010C\u00e1rdenas","sequence":"additional","affiliation":[{"name":"Hospital Guillermo Almenara Irigoyen, EsSalud Lima Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Re\u00e1tegui\u2010Sokolova","sequence":"additional","affiliation":[{"name":"Hospital Guillermo Almenara Irigoyen EsSalud and Unidad de Investigaci\u00f3n para la Generaci\u00f3n y S\u00edntesis de Evidencias en Salud Universidad San Ignacio de Loyola Lima Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariela","family":"Medina\u2010Chinch\u00f3n","sequence":"additional","affiliation":[{"name":"Hospital Guillermo Almenara Irigoyen, EsSalud Lima Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Zevallos","sequence":"additional","affiliation":[{"name":"Hospital Guillermo Almenara Irigoyen, EsSalud Lima Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Elera\u2010Fitzcarrald","sequence":"additional","affiliation":[{"name":"Hospital Guillermo Almenara Irigoyen EsSalud and School of Medicine Universidad Cient\u00edfica del Sur Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3638-7054","authenticated-orcid":false,"given":"Victor","family":"Pimentel\u2010Quiroz","sequence":"additional","affiliation":[{"name":"Hospital Guillermo Almenara Irigoyen, EsSalud Lima Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge M.","family":"Cucho\u2010Venegas","sequence":"additional","affiliation":[{"name":"Hospital Guillermo Almenara Irigoyen, EsSalud Lima Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoila","family":"Rodr\u00edguez\u2010Bellido","sequence":"additional","affiliation":[{"name":"Hospital Guillermo Almenara Irigoyen EsSalud and School of Medicine Universidad Nacional Mayor de San Marcos Lima Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar A.","family":"Pastor\u2010Asurza","sequence":"additional","affiliation":[{"name":"Hospital Guillermo Almenara Irigoyen EsSalud and School of Medicine Universidad Nacional Mayor de San Marcos Lima Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela S.","family":"Alarc\u00f3n","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Alabama at Birmingham and School of Medicine Universidad Peruana Cayetano Heredia Lima Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risto","family":"Perich\u2010Campos","sequence":"additional","affiliation":[{"name":"Hospital Guillermo Almenara Irigoyen EsSalud and School of Medicine Universidad Nacional Mayor de San Marcos Lima 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