{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:28:13Z","timestamp":1780471693561,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate safety and effectiveness of adalimumab (ADA) in polyarticular\u2010course juvenile idiopathic arthritis (JIA) in the STRIVE registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>STRIVE enrolled patients with polyarticular\u2010course JIA into 2 arms based on treatment with methotrexate (MTX) alone or ADA with\/without MTX (ADA \u00b1 MTX). Adverse events (AEs) per 100 patient\u2010years of observation time were analyzed by registry arm. Patients who entered the registry within 4 weeks of starting MTX or ADA \u00b1 MTX, defined as new users, were evaluated for change in disease activity assessed by the 27\u2010joint Juvenile Arthritis Disease Activity Score with the C\u2010reactive protein level (JADAS\u201027<jats:sub>CRP<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the 7\u2010year cutoff date (June 1, 2016), data from 838 patients were available (MTX arm n = 301, ADA \u00b1 MTX arm n = 537). The most common AEs were nausea (10.3%), sinusitis (4.7%), and vomiting (4.3%) in the MTX arm and arthritis (3.9%), upper respiratory tract infection (3.5%), sinusitis, tonsillitis, and injection site pain (3.0% each) in the ADA \u00b1 MTX arm. Rates of serious infection were 1.5 events\/100 patient\u2010years in the MTX arm and 2.0 events\/100 patient\u2010years in the ADA \u00b1 MTX arm. AE and serious AE rates were similar in patients receiving ADA with versus without MTX. No deaths or malignancies were reported. New users in the ADA \u00b1 MTX arm showed a trend toward lower mean JADAS\u201027<jats:sub>CRP<\/jats:sub> compared with new users in the MTX arm in the first year of STRIVE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The STRIVE registry 7\u2010year interim results support the idea that ADA \u00b1 MTX is well tolerated by most children. Registry median ADA exposure was 2.47 (interquartile range 1.0\u20133.6) years, with 42% of patients continuing ADA at the 7\u2010year cutoff date.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24044","type":"journal-article","created":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T10:49:29Z","timestamp":1566038969000},"page":"1420-1430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Safety and Effectiveness of Adalimumab in Patients With Polyarticular Course of Juvenile Idiopathic Arthritis: STRIVE Registry Seven\u2010Year Interim Results"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9478-2987","authenticated-orcid":false,"given":"Hermine I.","family":"Brunner","sequence":"first","affiliation":[{"name":"Pediatric Rheumatology Collaborative Study Group Cincinnati Children\u2019s Hospital Medical Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kabita","family":"Nanda","sequence":"additional","affiliation":[{"name":"University of Washington School of Medicine and Seattle Children\u2019s Hospital  Seattle"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Toth","sequence":"additional","affiliation":[{"name":"Nemours Children\u2019s Hospital  Orlando Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Foeldvari","sequence":"additional","affiliation":[{"name":"Hamburg Centre for Pediatric and Adolescence Rheumatology  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Bohnsack","sequence":"additional","affiliation":[{"name":"University of Utah  Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Milojevic","sequence":"additional","affiliation":[{"name":"Johns Hopkins All Children\u2019s Hospital  St. Petersburg Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Egla","family":"Rabinovich","sequence":"additional","affiliation":[{"name":"Duke University Medical Center  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Kingsbury","sequence":"additional","affiliation":[{"name":"Randall Children\u2019s Hospital at Legacy Emanuel  Portland Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Marzan","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Los Angeles  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Chalom","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Collaborative Study Group Cincinnati Children\u2019s Hospital Medical Center  Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Horneff","sequence":"additional","affiliation":[{"name":"Asklepios Klinik Sankt Augustin, Sankt Augustin, and University Hospital of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf\u2010Michael","family":"Kuester","sequence":"additional","affiliation":[{"name":"Orthopaediezentrum Altona  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason A.","family":"Dare","sequence":"additional","affiliation":[{"name":"Arkansas Children\u2019s Hospital  Little Rock Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Trachana","sequence":"additional","affiliation":[{"name":"Hippokration General Hospital Thessaloniki University School of Medicine  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence K.","family":"Jung","sequence":"additional","affiliation":[{"name":"Children\u2019s National Medical Center  Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judyann","family":"Olson","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin  Milwaukee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Minden","sequence":"additional","affiliation":[{"name":"Charite University Medicine Berlin and German Rheumatism Research Center  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Quartier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Descartes Institut IMAGINE and Centre de R\u00e9f\u00e9rence RAISE H\u00f4pital Necker\u2010Enfants Malades Assistance Publique\u2010H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mareike","family":"Bereswill","sequence":"additional","affiliation":[{"name":"AbbVie Deutschland GmbH and Co. 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