{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T14:41:25Z","timestamp":1759416085185,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T00:00:00Z","timestamp":1590451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care & Research"],"published-print":{"date-parts":[[2020,7]]},"abstract":"Objective<\/jats:title>High magnetic resonance imaging (MRI<\/jats:styled-content>)\u2013detected inflammation is associated with greater progression and poorer outcomes in rheumatoid arthritis (RA<\/jats:styled-content>). This analysis aimed to determine if baseline MRI<\/jats:styled-content> inflammation was related to clinical response and remission in the Assessing Very Early Rheumatoid arthritis Treatment (AVERT<\/jats:styled-content>) study.<\/jats:p><\/jats:sec>Methods<\/jats:title>AVERT<\/jats:styled-content> was a phase III<\/jats:styled-content>b, randomized, controlled trial with a 12\u2010month, double\u2010blind treatment period enrolling patients with early (\u22642 years' duration), anti\u2010citrullinated peptide\u2013positive methotrexate (MTX<\/jats:styled-content>)\u2010naive RA<\/jats:styled-content>. In this post hoc analysis, patients in the abatacept plus MTX<\/jats:styled-content> (n = 114) and MTX<\/jats:styled-content> (n = 111) arms with available MRI<\/jats:styled-content> results were stratified into low and high baseline MRI<\/jats:styled-content> inflammation groups based on previously developed cutoffs of synovitis and osteitis on unilateral hand\u2013wrist contrast\u2010enhanced MRI<\/jats:styled-content>. Simplified Disease Activity Index (SDAI<\/jats:styled-content>) remission (\u22643.3), Clinical Disease Activity Index (CDAI<\/jats:styled-content>) remission (\u22642.8), Boolean remission, and Disease Activity Score in 28 joints using the C\u2010reactive protein level (<2.6) were assessed.<\/jats:p><\/jats:sec>Results<\/jats:title>Overall, 100 of 225 patients (44.4%) had high baseline MRI<\/jats:styled-content> inflammation. In patients with high baseline MRI<\/jats:styled-content> inflammation, a significantly greater proportion achieved remission at 12 months with abatacept plus MTX<\/jats:styled-content> versus MTX<\/jats:styled-content> across SDAI<\/jats:styled-content> (45.1% versus 16.3%; P<\/jats:italic> = 0.0022), CDAI<\/jats:styled-content> (47.1% versus 20.4%; P<\/jats:italic> = 0.0065), and Boolean indices (39.2% versus 16.3%; P<\/jats:italic> = 0.0156). In patients with low baseline MRI<\/jats:styled-content> inflammation, remission rates were not significantly different with abatacept plus MTX<\/jats:styled-content> versus MTX<\/jats:styled-content> (SDAI<\/jats:styled-content>: 39.7% versus 32.3%; P<\/jats:italic> = 0.4961).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In seropositive, MTX<\/jats:styled-content>\u2010naive patients with early RA<\/jats:styled-content> and presence of objectively measured high inflammation by MRI<\/jats:styled-content>, indicating poor prognosis, remission rates were higher with abatacept plus MTX<\/jats:styled-content> treatment versus MTX<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24072","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T07:07:38Z","timestamp":1569308858000},"page":"959-964","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Baseline Objective Inflammation by Magnetic Resonance Imaging as a Predictor of Therapeutic Benefit in Early Rheumatoid Arthritis With Poor Prognosis"],"prefix":"10.1002","volume":"72","author":[{"given":"Harris A.","family":"Ahmad","sequence":"first","affiliation":[{"name":"Bristol Myers Squibb Princeton New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua F.","family":"Baker","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Philadelphia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikkel","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"Rigshospitalet, Glostrup, Denmark, and University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7429-8482","authenticated-orcid":false,"given":"Paul","family":"Emery","sequence":"additional","affiliation":[{"name":"University of Leeds and NIHR Leeds Biomedical Research Centre Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Durez","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Catholique de Louvain Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June","family":"Ye","sequence":"additional","affiliation":[{"name":"Bristol Myers Squibb Princeton New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhashis","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Bristol Myers Squibb Princeton New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3478-5665","authenticated-orcid":false,"given":"Philip G.","family":"Conaghan","sequence":"additional","affiliation":[{"name":"University of Leeds and NIHR Leeds Biomedical Research Centre Leeds 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with lack of damage progression","volume":"35","author":"Baker JF","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2011.08.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210715"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39480"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208258"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.031773"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-eular.1374"}],"container-title":["Arthritis Care & 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