{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:52:46Z","timestamp":1762005166469,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK","doi-asserted-by":"publisher","award":["Primary Care Centre of Excellence Award (20202)"],"award-info":[{"award-number":["Primary Care Centre of Excellence Award (20202)"]}],"id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000659","name":"Research Trainees Coordinating Centre","doi-asserted-by":"publisher","award":["HEE\/NIHR ICA Clinical Lecturer: ICA\u2010CL\u20102016\u201002\u2010014","NIHR SPCR GP Progression Fellowship"],"award-info":[{"award-number":["HEE\/NIHR ICA Clinical Lecturer: ICA\u2010CL\u20102016\u201002\u2010014","NIHR SPCR GP Progression Fellowship"]}],"id":[{"id":"10.13039\/501100000659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify distinct recovery trajectories of acute flares of knee pain and associated participant characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were from the FLARE randomized controlled trial, a multicenter trial in 27 primary care centers in the UK and Netherlands of 3 regimes of oral nonsteroidal antiinflammatory therapy for acute flares of knee pain. Individuals with a history of inflammatory\/crystal arthritis, fibromyalgia, and chronic pain syndrome were excluded. Latent class growth analysis was applied to measures of pain intensity repeated over 5 days to identify distinct recovery trajectories. The concurrent courses of interference with activity, stiffness, and swelling for each trajectory group were modelled using generalized estimating equations. Participant age, sex, obesity, and osteoarthritis diagnosis were described for each trajectory group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 449 participants were included (median age 55 years, 41% female, 35% obese, and 42% diagnosed with osteoarthritis). A 6\u2010group cubic model was deemed optimal, with trajectories distinguished by rate of pain reduction and absolute level at final measurement. At the extremes were rapid and near\u2010complete resolution (n = 41, 9%) and persistent, high pain (n = 25, 6%), but most participants showed a reduction and plateau in pain severity within 3\u20135 days. Within each pain trajectory group, interference with activity, stiffness, and swelling followed the same course as pain. Baseline characteristics did not differ substantially between trajectory groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Even under a well\u2010adhered to regime of oral nonsteroidal antiinflammatory medication, recovery following acute flares of knee pain is heterogeneous. Our observations that favorable trajectories are apparent within 3\u20135 days can help to inform treatment decision\u2010making in the patient\u2013health care professional consultation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24088","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T15:57:59Z","timestamp":1570723079000},"page":"1687-1692","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Short\u2010Term Recovery Trajectories of Acute Flares in Knee Pain: A UK\u2010Netherlands Multicenter Prospective Cohort Analysis"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4951-9925","authenticated-orcid":false,"given":"Martin J.","family":"Thomas","sequence":"first","affiliation":[{"name":"Keele University Haywood Academic Rheumatology Centre Midlands Partnership NHS Foundation Trust, and Haywood Hospital  Burslem Staffordshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dahai","family":"Yu","sequence":"additional","affiliation":[{"name":"Keele University  Staffordshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Nicholls","sequence":"additional","affiliation":[{"name":"Keele University  Staffordshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sita","family":"Bierma\u2010Zeinstra","sequence":"additional","affiliation":[{"name":"Erasmus MC\u2013University Medical Centre  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3478-5665","authenticated-orcid":false,"given":"Philip G.","family":"Conaghan","sequence":"additional","affiliation":[{"name":"University of Leeds and NIHR Leeds Biomedical Research Centre  Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen J.","family":"Stoner","sequence":"additional","affiliation":[{"name":"Infirst Healthcare Ltd  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuhina","family":"Neogi","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma L.","family":"Parry","sequence":"additional","affiliation":[{"name":"Keele University  Staffordshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Peat","sequence":"additional","affiliation":[{"name":"Keele University  Staffordshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.12.017"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-019804"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.161107"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202984"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.03.009"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.09.026"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2017.09.002"},{"key":"e_1_2_7_9_1","first-page":"1833","article-title":"Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee","volume":"15","author":"Bellamy N","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_7_10_1","first-page":"635","article-title":"Growth mixture modeling. 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