{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:52:01Z","timestamp":1761897121915,"version":"build-2065373602"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011951","name":"Sandvik","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011951","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005595","name":"University of California","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp;amp; Research"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine medication satisfaction and adherence and their relationships to disease variables and health\u2010related quality of life (HRQoL) in adults with juvenile idiopathic arthritis (JIA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients (n = 96, mean age 25 years, 67% female) completed questionnaires about their health status 19 years after disease onset. Patients receiving biologic disease\u2010modifying antirheumatic drugs (bDMARDs) or methotrexate (MTX) were assessed with the 8\u2010item Morisky Medication Adherence Scale (MMAS\u20108) and the Treatment Satisfaction Questionnaire for Medication (TSQM), including dimensions of effectiveness, side effects, convenience, and global satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DMARDs were received by 52 patients (54%) (mean age 25 years, 75% female), of which 28 received MTX and 37 received bDMARDs. Patients receiving combination therapy of MTX and bDMARDs (n = 15) reported higher satisfaction with bDMARDs than MTX in the dimensions of side effects and global satisfaction (mean \u00b1 SD 92.9 \u00b1 15.5 versus 56.2 \u00b1 30.9, and mean \u00b1 SD 67.6 \u00b1 19.8 versus 47.1 \u00b1 21.7; <jats:italic>P<\/jats:italic> &lt; 0.001 and <jats:italic>P<\/jats:italic> = 0.016, respectively). Patients receiving either bDMARDs (n = 22) or MTX (n = 13) reported higher satisfaction with bDMARDs than MTX for the dimensions of effectiveness and global satisfaction (mean \u00b1 SD 78.7 \u00b1 15.4 versus 60.2 \u00b1 19.9, and mean \u00b1 SD 73.6 \u00b1 17.7 versus 52.3 \u00b1 23.9; <jats:italic>P<\/jats:italic> = 0.004 and <jats:italic>P<\/jats:italic> = 0.005, respectively). Nearly one\u2010half of patients (46%) reported low adherence (MMAS\u20108 score &lt;6) and 25% high adherence (MMAS\u20108 score = 8). Higher levels of pain, psychological distress, more active joints, and current MTX use were the strongest correlates of lower medication satisfaction. Perceived medication effectiveness and global satisfaction correlated positively with physical and mental HRQoL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with JIA were more satisfied with bDMARDs than MTX, and 46% reported low adherence. Higher medication satisfaction was associated with better HRQoL.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24113","type":"journal-article","created":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T04:56:37Z","timestamp":1574484997000},"page":"221-231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Treatment Satisfaction With and Adherence to Disease\u2010Modifying Antirheumatic Drugs in Adult Patients With Juvenile Idiopathic Arthritis"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4776-9808","authenticated-orcid":false,"given":"Anita","family":"Tollisen","sequence":"first","affiliation":[{"name":"Oslo University Hospital Rikshospitalet Unger\u2010Vetlesens Institute Lovisenberg Diaconal Hospital, and University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berit","family":"Flat\u00f8","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Rikshospitalet and University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne M.","family":"Selvaag","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Rikshospitalet  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Aasland","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Rikshospitalet  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trude","family":"Ingebrigtsen","sequence":"additional","affiliation":[{"name":"Oslo University Hospital Rikshospitalet  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Sagen","sequence":"additional","affiliation":[{"name":"Children and Youth Rheumatology Association  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anners","family":"Lerdal","sequence":"additional","affiliation":[{"name":"Lovisenberg Diaconal Hospital and University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-6581-4.10013-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206034"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120602"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2014.03.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev398"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23709"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.073445"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket248"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2004.72252.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22907"},{"volume-title":"Adherence to long\u2010term therapies: evidence for action","year":"2003","author":"Sabat\u00eb E","key":"e_1_2_7_12_1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.141371"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-010-1774-x"},{"volume-title":"Constitution of the World Health Organization basic document","year":"1948","author":"World Health Organization","key":"e_1_2_7_15_1"},{"key":"e_1_2_7_16_1","first-page":"121","article-title":"Association between perceived treatment adherence and health\u2010related quality of life in children with juvenile idiopathic arthritis: perspectives of both parents and children","volume":"2","author":"April KT","year":"2008","journal-title":"Patient Prefer Adherence"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21609"},{"key":"e_1_2_7_18_1","first-page":"1122","article-title":"Early disease course and predictors of disability in juvenile rheumatoid arthritis and juvenile spondyloarthropathy: a 3 year prospective study","volume":"32","author":"Selvaag AM","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140073"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-2-12"},{"key":"e_1_2_7_21_1","first-page":"59","article-title":"New medication adherence scale versus pharmacy fill rates in seniors with hypertension","volume":"15","author":"Krousel-Wood M","year":"2009","journal-title":"Am J Manag Care"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2008.07572.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.09.002"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199603000-00003"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230202"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/nur.4770130405"},{"key":"e_1_2_7_27_1","first-page":"129","article-title":"Pain assessment: global use of the Brief Pain Inventory","volume":"23","author":"Cleeland CS","year":"1994","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1993.tb03388.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22719"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24087"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-013-0351-2"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20460"},{"key":"e_1_2_7_33_1","first-page":"480","article-title":"Psychological side effects of MTX treatment in juvenile idiopathic arthritis: a pilot study","volume":"25","author":"Van der Meer A","year":"2007","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30367"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2389-x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.068296"},{"key":"e_1_2_7_37_1","first-page":"589","article-title":"Drug adherence to biologic DMARDS with a special emphasis on the benefits of subcutaneous abatacept","volume":"6","author":"Malaviya AP","year":"2012","journal-title":"Patient Prefer Adherence"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev429"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120110"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev195"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38223"},{"key":"e_1_2_7_42_1","first-page":"1369","article-title":"Functioning and preferences for improvement of health among patients with juvenile idiopathic arthritis in early adulthood using the WHO ICF model","volume":"33","author":"Arkela\u2010Kautiainen M","year":"2006","journal-title":"J Rheumatol"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21985"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.075895"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39234"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-015-0052-6"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22534"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/NOR.0b013e3181e5c2c9"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22104"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-014-0410-2"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S24752"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.24113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acr.24113","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.24113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T14:33:29Z","timestamp":1759415609000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.24113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/acr.24113"],"URL":"https:\/\/doi.org\/10.1002\/acr.24113","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"type":"print","value":"2151-464X"},{"type":"electronic","value":"2151-4658"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"2019-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}