{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:55:28Z","timestamp":1780469728333,"version":"3.54.1"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T00:00:00Z","timestamp":1622678400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acrjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Arthritis Care &amp; Research"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Magnetic resonance imaging (MRI) is pivotal in the assessment of early sacroiliitis in children. We aimed to evaluate the agreement between local radiology reports and central imaging reviewers for active inflammation and structural damage at the sacroiliac (SI) joints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight hospitals each contributed up to 20 cases of consecutively imaged children and adolescents with juvenile idiopathic arthritis and suspected sacroiliitis. Studies were independently reviewed by 3 experienced musculoskeletal pediatric radiologists. Local assessments of global impression and lesions were coded from the local radiology reports by 2 study team members. Test properties of local reports were calculated using the central imaging team\u2019s majority as the reference standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For 120 evaluable subjects, the median age was 14 years, half of the cases were male, and median disease duration at the time of imaging was 0.8 years (interquartile range 0\u20132). Sensitivity of local reports for inflammation was high, 93.5% (95% confidence interval [95% CI] 78.6\u201399.2), and specificity was moderate, 69.7% (95% CI 59.0\u201379.0), but positive predictive value (PPV) was low, 51.8% (95% CI 38.0\u201365.3). Twenty\u2010seven cases (23%) had active inflammation reported locally but rated normal at the central reading, 19 (70%) with subsequent medication changes. The sensitivity of local reports detecting structural damage was low, 45.7% (95% CI 28.8\u201363.4), and specificity was high, 88.2% (95% CI 79.4\u201394.2); PPV was low, 61.5% (95% CI 40.6\u201379.8).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Substantial variation exists in the interpretation of inflammatory and structural lesions at the SI joints in children. To reliably identify pathology, additional training in the MRI appearance of the maturing SI joint is greatly needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/acr.24206","type":"journal-article","created":{"date-parts":[[2020,4,11]],"date-time":"2020-04-11T07:48:37Z","timestamp":1586591317000},"page":"841-848","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Variability in Interpretation of Magnetic Resonance Imaging of the Pediatric Sacroiliac Joint"],"prefix":"10.1002","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9724-0443","authenticated-orcid":false,"given":"Pamela F.","family":"Weiss","sequence":"first","affiliation":[{"name":"Children\u2019s Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine  Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1305-4871","authenticated-orcid":false,"given":"Timothy G.","family":"Brandon","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Philadelphia  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Bohnsack","sequence":"additional","affiliation":[{"name":"University of Utah  Salt Lake City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9488-6476","authenticated-orcid":false,"given":"Merav","family":"Heshin\u2010Bekenstein","sequence":"additional","affiliation":[{"name":"University of California, San Francisco and Dana Children\u2019s Hospital of Tel Aviv Medical Center Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael\u00a0L.","family":"Francavilla","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine  Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob L.","family":"Jaremko","sequence":"additional","affiliation":[{"name":"University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lester","family":"Liao","sequence":"additional","affiliation":[{"name":"University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"McHugh","sequence":"additional","affiliation":[{"name":"Stanford University, Stanford, California, and Wright State University Boonshoft School of Medicine  Dayton Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2171-9340","authenticated-orcid":false,"given":"Edward J.","family":"Oberle","sequence":"additional","affiliation":[{"name":"Ohio State University College of Medicine and Nationwide Children\u2019s Hospital  Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dax","family":"Rumsey","sequence":"additional","affiliation":[{"name":"University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemalatha","family":"Srinivasalu","sequence":"additional","affiliation":[{"name":"Children\u2019s National Health System  Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Stoll","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy A.","family":"Chauvin","sequence":"additional","affiliation":[{"name":"Penn State Milton S. Hershey Children\u2019s Hospital  Hershey Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23870"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.18.20708"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2012.01564.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-018-4185-x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1642-8"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1543-x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.171329"},{"issue":"2","key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1136\/annrheumdis-2018-eular.6880","article-title":"Validation of web\u2010based calibration modules for imaging scoring systems based on principles of artificial intelligence: the SPARCC MRI sacroiliac joint inflammation score [abstract]","volume":"77","author":"Maksymowych WP","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_7_11_1","article-title":"MRI lesion definitions in axial spondyloarthritis: a consensus reappraisal from the Assessments in SpondyloArthritis International Society (ASAS) [abstract]","author":"Maksymowych W","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_7_12_1","article-title":"The contribution of structural MRI lesions to detection of sacroiliitis in patients in the assessments in SpondyloArthritis International Society (ASAS) classification cohort [abstract]","author":"Maksymowych W","journal-title":"Ann Rheum Dis"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208642"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2018.11.011"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.9105"}],"container-title":["Arthritis Care &amp; Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Facr.24206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.24206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/acr.24206","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/acr.24206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T14:31:38Z","timestamp":1759415498000},"score":1,"resource":{"primary":{"URL":"https:\/\/acrjournals.onlinelibrary.wiley.com\/doi\/10.1002\/acr.24206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/acr.24206"],"URL":"https:\/\/doi.org\/10.1002\/acr.24206","archive":["Portico"],"relation":{},"ISSN":["2151-464X","2151-4658"],"issn-type":[{"value":"2151-464X","type":"print"},{"value":"2151-4658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"2019-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}